Document 1212
 DOCN  M9591212
 TI    Virologic and immunologic characterization of symptomatic and
       asymptomatic primary HIV-1 infection.
 DT    9509
 AU    Henrard DR; Daar E; Farzadegan H; Clark SJ; Phillips J; Shaw GM; Busch
       MP; Department of Medical Research, Abbott Laboratories, Abbott Park,;
       Illinois, USA.
 SO    J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jul 1;9(3):305-10.
       Unique Identifier : AIDSLINE MED/95308208
 AB    To define virologic and immunologic differences in patients with acute
       symptomatic and asymptomatic primary human immunodeficiency virus type 1
       (HIV-1) infection, sequential plasma specimens were obtained
       longitudinally for 1-2 years postseroconversion from subjects with
       well-documented time of seroconversion. Thirteen of them had an acute
       symptomatic primary infection, eight subjects had asymptomatic primary
       infection and long-term follow-up, and 27 had asymptomatic
       seroconversion and short-term follow-up. Quantitative plasma HIV-1 RNA
       levels, CD4+ lymphocyte counts, and levels of antibodies to gp120, p66,
       p41, p31, p24, and p17 were measured. At the time of seroconversion,
       there was no significant difference in HIV-1 RNA levels and CD4+ counts
       between symptomatic (n = 13) and asymptomatic (n = 27) subjects.
       Subsequently, however, establishment of low levels of plasma HIV-1 RNA
       was seen significantly more frequently in asymptomatic (n = 8) than in
       symptomatic (n = 13) primary infection; this correlated with higher
       levels of some (anti-gp120 and anti-p31) anti-HIV-1 antibodies and a
       slower decline in CD4+ lymphocyte counts. These results indicate that
       immunologic control of viremia early after infection may be a critical
       determinant to subsequent clinical course of HIV-1 infection. They also
       suggest that persons with acute symptomatic primary infection may
       generally progress to having acquired immune deficiency syndrome (AIDS)
       more rapidly than people with low-grade symptoms or asymptomatic primary
       infection.
 DE    Acquired Immunodeficiency Syndrome/IMMUNOLOGY  Acute Disease
       Comparative Study  CD4 Lymphocyte Count  Female  Human  HIV
       Antibodies/ANALYSIS  HIV Antigens/IMMUNOLOGY  HIV Core Protein p24/BLOOD
       HIV Infections/*IMMUNOLOGY/VIROLOGY  HIV Seropositivity/IMMUNOLOGY
       HIV-1/GENETICS/*IMMUNOLOGY  Male  RNA, Viral/BLOOD
       Viremia/*IMMUNOLOGY/VIROLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).