Document 1213
 DOCN  M9591213
 TI    Incubation period of vertically acquired AIDS in Europe before
       widespread use of prophylactic therapies.
 DT    9509
 AU    Downs AM; Salamina G; Ancelle-Park RA; European Centre for the
       Epidemiological Monitoring of AIDS,; Saint-Maurice, Paris, France.
 SO    J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jul 1;9(3):297-304.
       Unique Identifier : AIDSLINE MED/95308207
 AB    European surveillance data on vertically acquired (VA) AIDS cases were
       used to investigate the incubation period of AIDS in the absence of
       widespread prophylactic treatment and to assess the uncertainty
       associated with parametric estimates based on retrospective data.
       Nonparametric and parametric analyses, taking into account the effects
       of data truncation, were based on a total of 792 children diagnosed with
       AIDS between July, 1982, and June, 1990, inclusive. Among HIV-infected
       children who develop AIDS within 8 years, the nonparametric estimate of
       the median age at diagnosis was 34 months. If 20% of children are
       assumed to develop AIDS by the age of 1 year (a plausible estimate on
       the basis of published cohort data), the estimated median among all
       maternally HIV-infected children is 4.4 years, with 26% of children
       expected to remain AIDS free by 8 years of age. Results from the
       parametric (double Weibull) model support the hypothesis of a bimodal
       distribution, with a subgroup of children progressing rapidly to AIDS at
       a median age of approximately 5 months. However, neither the relative
       size of this group nor the median age at which AIDS develops in the
       remaining children can yet be estimated with any reasonable precision.
 DE    Acquired Immunodeficiency Syndrome/*DIAGNOSIS/EPIDEMIOLOGY/  PREVENTION
       & CONTROL/*TRANSMISSION  Antiviral Agents/THERAPEUTIC USE  Child  Child,
       Preschool  *Disease Transmission, Vertical  Europe/EPIDEMIOLOGY  Female
       Human  Infant  Infant, Newborn  Male  Models, Statistical  Pregnancy
       Pregnancy Complications, Infectious/*DIAGNOSIS/EPIDEMIOLOGY  Probability
       Retrospective Studies  Statistics, Nonparametric  Support, Non-U.S.
       Gov't  Time Factors  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).