Document 1214
 DOCN  M9591214
 TI    Recent infection with human immunodeficiency virus and possible rapid
       loss of CD4 T lymphocytes.
 DT    9509
 AU    Holmberg SD; Conley LJ; Luby SP; Cohn S; Wong LC; Vlahov D; Division of
       HIV/AIDS, Centers for Disease Control and Prevention,; Atlanta, GA
       30333, USA.
 SO    J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jul 1;9(3):291-6.
       Unique Identifier : AIDSLINE MED/95308206
 AB    To assess a hypothesized trend that persons recently infected with the
       human immunodeficiency virus (HIV) may have more rapid declines in
       absolute CD4 T-lymphocyte (CD4+ cell) counts than those who were
       HIV-infected in earlier years, sequential CD4+ cell counts in three
       groups who had definable dates of HIV seroconversion between 1978 and
       1992 were reviewed. The CD4+ cell counts examined were from some of the
       longest extant studies in the United States: 100 homosexual and bisexual
       men engaged in ongoing observational cohort studies in San Francisco,
       Denver, and Chicago since 1978 (Group 1); 89 persons in South Carolina
       infected after 1986 (Group 2); and 155 injecting drug users
       participating in an observational cohort study in Baltimore since 1988
       (Group 3). For all groups, individually and in the aggregate, mean CD4+
       cell counts declined rapidly in the first year after HIV infection and
       then stabilized. However, there was no clear trend for lower (or higher)
       CD4+ cell counts by fixed time after HIV seroconversion among those
       seroconverting in recent compared with earlier calendar years. These
       data do not support a hypothesized trend for more rapid loss of CD4 T
       lymphocytes--and, by implication, more pathogenic strains of
       HIV-1--among persons acquiring HIV infection in recent years.
 DE    Cell Death  Cohort Studies  CD4 Lymphocyte Count  CD4-Positive
       T-Lymphocytes/*IMMUNOLOGY  Human  HIV Infections/*IMMUNOLOGY  HIV
       Seropositivity  HIV-1/*IMMUNOLOGY  *Lymphocyte Depletion  Male
       Retrospective Studies  Time Factors  United States  JOURNAL ARTICLE
       MULTICENTER STUDY

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