Document 1222
 DOCN  M9591222
 TI    A prospective study of mother-to-infant HIV transmission in tribal women
       from India.
 DT    9509
 AU    Kumar RM; Uduman SA; Khurranna AK; Department of Obstetrics and
       Gynaecology, Faculty of Medicine and; Health Sciences, UAE University,
       Al Ain.
 SO    J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jul 1;9(3):238-42.
       Unique Identifier : AIDSLINE MED/95308198
 AB    The transmission of human immunodeficiency virus type 1 from infected
       mothers to their babies was assessed by serologic, virologic, and
       clinical means. Of the 160 antibody-positive women enrolled at the
       beginning of the study, 13 had overt clinical symptoms (CDC stage
       III/IV). Termination of pregnancy was done, on request, in seven of
       these cases. The rest delivered prematurely. A total of 143 parturient
       women and their infants were followed prospectively until the babies
       were 18 months of age. Fifteen infants (9%) died of AIDS before 14
       months of age. The remaining 128 children (91%) were alive at the end of
       the study period. Seventy-four seropositive children (46%) became
       seronegative and were considered noninfected. None of the seronegative
       children reverted to seropositive status despite the fact that they were
       breast-fed. The majority of the seropositive children (63%) became
       symptomatic and clinically ill during infancy. The overall
       mother-to-infant vertical transmission rate was 48%.
 DE    Adult  *Disease Transmission, Vertical  Ethnic Groups  Female  Follow-Up
       Studies  Human  HIV Antibodies/ANALYSIS  HIV Core Protein p24/ANALYSIS
       HIV Infections/DIAGNOSIS/MORTALITY/*TRANSMISSION  HIV
       Seropositivity/DIAGNOSIS  *HIV-1/IMMUNOLOGY/ISOLATION & PURIF  Incidence
       India/EPIDEMIOLOGY  Infant, Newborn  Placenta/VIROLOGY  Pregnancy
       Pregnancy Complications, Infectious/DIAGNOSIS/*EPIDEMIOLOGY  Prospective
       Studies  Virus Cultivation  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).