Document 1237
 DOCN  M9591237
 TI    Acute myeloblastic leukemia associated with an intermediate state
       between the healthy carrier state and adult T-cell leukemia.
 DT    9509
 AU    Kawachi Y; Watanabe A; Sakamoto Y; Abe T; Uchida T; Sacho M; Mori M;
       Setsu K; Department of Internal Medicine, Takamatsu Red Cross Hospital,;
       Kagawa, Japan.
 SO    Leuk Lymphoma. 1995 Feb;16(5-6):505-9. Unique Identifier : AIDSLINE
       MED/95307458
 AB    This report describes an intermediate state between the human T-cell
       lymphotropic virus type I (HTLV-I) healthy carrier and adult T-cell
       Leukemia (ATL) who developed acute myeloblastic leukemia (AML, FAB
       subtype M2). The polyclonal integration of HTLV-I proviral DNA was
       demonstrated in the peripheral blood lymphoid cells, whereas AML cells
       had no HTLV-I proviral DNA. The patient achieved remission after
       combination chemotherapy but cells with lobulated nuclei persist at a
       low level and the polyclonal integration of HTLV-I proviral DNA is still
       demonstrated. We suggest that the patients with the integration of
       HTLV-I proviral DNA might develop secondary neoplasms more frequently
       than healthy carriers and this case stresses the need to exercise
       caution with these patients. The relationship between HTLV-I and AML is
       briefly discussed.
 DE    Adult  *Carrier State/VIROLOGY  Case Report  Disease Susceptibility
       DNA, Viral/ISOLATION & PURIF  Human  HTLV-I/ISOLATION & PURIF
       Immunocompromised Host  *Leukemia-Lymphoma, T-Cell, Acute,
       HTLV-I-Associated/VIROLOGY  *Leukemia, Myelocytic, Acute  Male
       *Neoplasms, Multiple Primary  Proviruses/ISOLATION & PURIF  Tumor Stem
       Cells/PATHOLOGY/VIROLOGY  JOURNAL ARTICLE  REVIEW  REVIEW OF REPORTED
       CASES

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