Document 1239
 DOCN  M9591239
 TI    Adhesion properties of adult T cell leukemia cells.
 DT    9509
 AU    Uchiyama T; Ishikawa T; Imura A; Research Center for Immunodeficiency
       Virus, Kyoto University,; Japan.
 SO    Leuk Lymphoma. 1995 Feb;16(5-6):407-12. Unique Identifier : AIDSLINE
       MED/95307444
 AB    The interaction between neoplastic as well as normal T cells and
       vascular endothelial cells which is mediated by adhesion molecules play
       a key role in their trafficking, localization and infiltration. This
       brief article reviews our studies on the expression of adhesion
       molecules on leukemic cells isolated from patients with adult T cell
       leukemia (ATL) and HTLV-I-infected T cell line cells and on their
       adhesion to human umbilical vein endothelial cells (HUVEC). Fresh ATL
       cells expressed lymphocyte function-associated antigen-1 (LFA-1), but
       the expression of very late antigen-4 (VLA-4) and sialyl-Lewis(x) (SLex)
       was variable. Sialyl Lewis(a) (SLea) was not detected. Cell adhesion
       assays using HUVEC and adhesion-blocking antibodies revealed the
       consistent E-selectin-mediated adhesion and variable VLA-4-mediated
       adhesion of ATL cells to HUVEC. The studies on HTLV-I-infected T cell
       lines confirmed the above data. These results, together with the
       detection of E-selectin expression on the endothelium of the skin
       infiltrated with ATL cells, indicate that E-selectin-mediated adhesion
       is the major pathway for the adherence of ATL cells to endothelial
       cells. The possible role of such adhesion in the formation of skin
       lesions and other clinical manifestations of ATL which result from the
       infiltration of leukemic cells is discussed.
 DE    Cell Adhesion  Cell Adhesion Molecules/*PHYSIOLOGY  Cell Movement
       Cells, Cultured  Endothelium, Vascular/CYTOLOGY  Human
       Leukemia-Lymphoma, T-Cell, Acute, HTLV-I-Associated/*PATHOLOGY  Neoplasm
       Proteins/*PHYSIOLOGY  Receptors, Cytoadhesin/PHYSIOLOGY  Tumor Stem
       Cells/*PATHOLOGY  Umbilical Veins  JOURNAL ARTICLE

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