Document 1251
 DOCN  M9591251
 TI    The role of cytokines in the acquired immunodeficiency syndrome.
 DT    9509
 AU    Yamamoto N; Department of Microbiology, Tokyo Medical and Dental
       University; School of Medicine, Japan.
 SO    Int J Clin Lab Res. 1995;25(1):29-34. Unique Identifier : AIDSLINE
       MED/95306813
 AB    HIV replication in vitro is regulated by many factors, including various
       exogeneous stimuli and proteins encoded by either virus or cellular
       genomes. During the asymptomatic period, cells latently or chronically
       infected with HIV gradually express virus, leading to immunosuppression
       and opportunistic infection. These conditions would result in the
       increased secretion of cytokines, especially TNF, from infected and
       uninfected cells, which can induce HIV and killing of infected cells. A
       vicious circle is then set in motion in which heterologous microbial
       infections directly or indirectly activate HIV and the production of
       cytokines, thereby accelerating lymphocyte depletion and
       immunodeficiency. AIDS is a disorder of the immune network caused by a
       unique retrovirus HIV. However, if the whole story described above is
       true, this disease can also be termed a cytokine disease. Immunity
       resembles a double-edged sword, with aspects not only protective, but
       also deleterious to the host. Therefore, it is essential to more
       extensively investigate the mechanism of cytokine regulation of HIV
       expression in vivo, not only to understand the complex pathophysiology
       of AIDS, but also to design a therapeutic strategy to halt this deadly
       disease.
 DE    Acquired Immunodeficiency Syndrome/*IMMUNOLOGY  Cytokines/*IMMUNOLOGY
       Human  Support, Non-U.S. Gov't  JOURNAL ARTICLE  REVIEW  REVIEW,
       TUTORIAL

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