Document 1261
 DOCN  M9591261
 TI    [HTLV-I-associated neuropathy]
 DT    9509
 AU    Kanzaki A; Yabuki S; Shirabe T; Department of Neurology, Kochi Municipal
       Central Hospital, Japan.
 SO    No To Shinkei. 1995 May;47(5):497-501. Unique Identifier : AIDSLINE
       MED/95306191
 AB    A 70-year-old man was admitted to our hospital because of a 15-year
       history of walking difficulty, disturbance of sensation in the palm for
       2 years and hand tremor for 6 months. On admission, the scapulohumeral
       muscles showed fasciculation and atrophy. There was action tremor in the
       upper limb, and the proximal lower limb showed atrophy and weakness.
       Standing and walking were impossible. Deep tendon reflexes were
       decreased in lower limbs. Pathologic reflexes were not found. There was
       distal dominant sensory disturbance, and urination was difficult. Needle
       EMG showed a neurogenic pattern in 4 all limbs. MCV and F-latency were
       delayed. SCV in the median nerve and the amplitude in the sural nerve
       were decreased. Biopsy of the sural nerve revealed both axonal change
       and demyelination. Biopsy of the quadriceps femoris muscle showed
       neurogenic change with helper T-cell infiltration. Anti-HTLV-I antibody
       and ATL-like cells in both blood and CSF were positive. There were
       HTLV-I provirus DNA with a polyclonal pattern and the type of HLA as
       HAM. The HTLV-I infection was of the HAM type. As the present patient
       showed mainly neuropathy without pyramidal signs, was not considered to
       have HAM.
 DE    Aged  Axons/PATHOLOGY  Case Report  Demyelinating Diseases/ETIOLOGY
       DNA, Viral/ANALYSIS  English Abstract  Human  HTLV-I Antibodies/ANALYSIS
       HTLV-I Infections/*COMPLICATIONS/PATHOLOGY  Male  Nervous System
       Diseases/*ETIOLOGY/PATHOLOGY  JOURNAL ARTICLE

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