Document 1264
 DOCN  M9591264
 TI    Differential Tax expression in HTLV type I-infected asymptomatic
       carriers.
 DT    9509
 AU    Major M; Daenke S; Nightingale S; Desselberger U; Department of
       Pathology, University of Cambridge, England.
 SO    AIDS Res Hum Retroviruses. 1995 Mar;11(3):415-21. Unique Identifier :
       AIDSLINE MED/95306146
 AB    tax gene expression in a family cluster of three HTLV-I-infected
       asymptomatic individuals was investigated. Two carriers had normal tax
       mRNA, Tax-specific humoral antibody, and cell-mediated immune (CMI)
       response. In one carrier who had only weak Tax-specific humoral and no
       Tax-specific CMI response, an abnormal Tax-related mRNA product was
       detected. This product was sequenced and found to consist of two exons
       derived from the LTR gag and pX regions. The abnormal mRNA has an ORF
       predicting a 17-kDa protein, the translation of which is initiated in
       the first exon. The presence of this protein, of antibody to it, and of
       its function remain to be elucidated.
 DE    Amino Acid Sequence  Base Sequence  Carrier
       State/BLOOD/IMMUNOLOGY/*VIROLOGY  Comparative Study  DNA Primers  *Gene
       Expression  Gene Products, tax/*BIOSYNTHESIS  Genes, env  Genes, gag
       *Genes, pX  Genes, Reiterated  Genome, Viral  Human
       HTLV-I/*GENETICS/ISOLATION & PURIF  HTLV-I Antibodies/*BLOOD  HTLV-I
       Infections/BLOOD/IMMUNOLOGY/*VIROLOGY  Molecular Sequence Data  Open
       Reading Frames  Polymerase Chain Reaction  Repetitive Sequences, Nucleic
       Acid  RNA, Messenger/ANALYSIS/BIOSYNTHESIS  Support, Non-U.S. Gov't
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).