Document 1272
 DOCN  M9591272
 TI    Lymphocytotropic strains of HIV type 1 when complexed with enhancing
       antibodies can infect macrophages via Fc gamma RIII, independently of
       CD4.
 DT    9509
 AU    Trischmann H; Davis D; Lachmann PJ; MRC Centre, Molecular
       Immunopathology Unit, Cambridge, UK.
 SO    AIDS Res Hum Retroviruses. 1995 Mar;11(3):343-52. Unique Identifier :
       AIDSLINE MED/95306138
 AB    Antipeptide sera raised against the gp120/gp41 sequences of human
       immunodeficiency virus type 1 (HIV-1) were used to determine their
       capacity to enhance infection. Antisera to the five variable regions (V1
       to V5) of gp120 and conserved parts of gp120 and gp41 facilitated
       infection of primary human macrophages with the homologous virus HIV-1
       SF2mc. In contrast, heterologous virus infection with HTLV-IIIB was
       mediated only by antisera to the conserved regions, predominantly C4 and
       C5. Heterologous virus infection occurred more rapidly and was
       consistent between different cell donors. The neutralizing monoclonal
       antibody (MAb) SC258 (murine IgG2a) but not MAb 684-238 (mIgG1) against
       conformational epitopes of the V2 region also induced antibody-dependent
       infection enhancement (ADE). Therefore, preincubation with certain
       antibodies can cause altered tropism of the lymphocytotropic viruses
       mentioned above. Viral infection was completely abolished by
       preincubation with the F(ab)2 fragment of MAb 3G8 against the Fc gamma
       receptor III (CD16). A MAb (7.3F11) against the gp120-binding site of
       CD4 had no effect on viral infectivity. Possible mechanisms and their
       implications for disease progression are discussed.
 DE    Acquired Immunodeficiency Syndrome/BLOOD/*IMMUNOLOGY  Antibodies,
       Monoclonal/*IMMUNOLOGY  Antigenic Determinants/CHEMISTRY/IMMUNOLOGY
       Antigens, CD/*IMMUNOLOGY  Antigens, CD4/*IMMUNOLOGY  Cell Line
       Comparative Study  Disease Progression  Flow Cytometry  Human  HIV
       Envelope Protein gp120/*IMMUNOLOGY  HIV Envelope Protein
       gp41/*IMMUNOLOGY  HIV Infections/IMMUNOLOGY
       HIV-1/IMMUNOLOGY/*PHYSIOLOGY/*PATHOGENICITY
       Macrophages/*IMMUNOLOGY/*VIROLOGY  Models, Immunological  Neutralization
       Tests  Protein Conformation  Receptors, IgG/*PHYSIOLOGY  Support,
       Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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