Document 1280
 DOCN  M9591280
 TI    Adult T-cell leukemia/lymphoma in a Korean--a case report.
 DT    9509
 AU    Lee SS; Hong SI; Lee DS; Kang YK; Kim CW; Jang JJ; Department of
       Anatomic Pathology, Korea Cancer Center Hospital,; Seoul.
 SO    J Korean Med Sci. 1994 Dec;9(6):458-65. Unique Identifier : AIDSLINE
       MED/95305991
 AB    The clinicopathologic features of a Korean patient with adult T-cell
       leukemia/lymphoma(ATLL) are presented. A 51-year-old man, who has lived
       in Korea since birth, had multiple cutaneous nodules and multiple
       lymphadenopathy for the previous two months. A histopathologic study of
       the lymph node and skin lesion revealed T-cell non-Hodgkin's lymphoma of
       pleomorphic type, medium and large cell type. Peripheral blood
       examination showed leukemic features with 30% of abnormal lymphoid
       cells. HTLV-I proviral DNA pX region was detected in the DNA from
       peripheral blood mononuclear cells(PBMC) and the specific gag, pol, and
       env HTLV-I sequences were detected in the lymph node using polymerase
       chain reaction technique. Human T-cell leukemia/lymphoma type I(HTLV-I)
       antibodies were present in the serum. An immunophenotypic study of the
       lymph node revealed CD4 positive and CD8 negative helper/inducer T cell
       type surface markers. This case is the acute type, i.e. prototypic ATLL.
       He was treated with an intensive chemotherapy including
       cyclophosphamide, etoposide, doxorubicin, vincristine, and prednisone.
       Despite initial transient improvement, the tumor progressed after three
       cycles of the regimen and became refractory to further chemotherapy.
       These clinicopathologic findings, including the immunophenotypic
       analysis, established with certainty the diagnosis of HTLV-I-induced
       adult T-cell leukemia/lymphoma.
 DE    Antineoplastic Agents, Combined/THERAPEUTIC USE  Case Report
       Cyclophosphamide/ADMINISTRATION & DOSAGE  Doxorubicin/ADMINISTRATION &
       DOSAGE  DNA, Viral/BLOOD  Etoposide/ADMINISTRATION & DOSAGE  Human
       HTLV-I/ISOLATION & PURIF  Immunophenotyping  Korea/EPIDEMIOLOGY
       *Leukemia-Lymphoma, T-Cell, Acute, HTLV-I-Associated/DRUG THERAPY/
       EPIDEMIOLOGY/PATHOLOGY/VIROLOGY  Lymph Nodes/PATHOLOGY  Male  Middle Age
       Prednisone/ADMINISTRATION & DOSAGE  Proviruses/ISOLATION & PURIF  Tumor
       Stem Cells/CHEMISTRY/PATHOLOGY  Vincristine/ADMINISTRATION & DOSAGE
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).