Document 0006
 DOCN  M95A0006
 TI    The changing face of tuberculosis.
 DT    9510
 AU    Huebner RE; Castro KG; Division of Tuberculosis Elimination, Centers for
       Disease Control; and Prevention, Atlanta, Georgia 30333, USA.
 SO    Annu Rev Med. 1995;46:47-55. Unique Identifier : AIDSLINE MED/95321695
 AB    Tuberculosis (TB) remains an important public health problem worldwide,
       resulting in a estimated 8 to 10 million new cases and 2 to 3 million
       deaths each year. Between 1953 and 1985, the number of TB cases in the
       US declined by an average of 6% per year. However, since 1985, TB has
       been increasing in the US. Approximately 64,000 additional cases of the
       disease have been reported beyond the number expected had the rate of
       decline observed from 1980 to 1984 continued from 1985 through 1993.
       Increases in the number of TB cases have been significant in racial and
       ethnic minorities, in persons born outside the US, and in children less
       than 15 years of age. Infection with the human immunodeficiency virus
       (HIV) has also been recognized as a major risk factor for the
       development of active TB in persons with latent Mycobacterium
       tuberculosis infection. The unusual radiographic findings and the
       increased likelihood of extrapulmonary TB in HIV-infected persons make
       diagnosis of the disease problematic. Lastly, concomitant with the
       resurgence of TB has been the emergence of drug resistance. All of these
       factors make successful control of TB in the US difficult.
 DE    Adult  Antitubercular Agents/ADVERSE EFFECTS/*THERAPEUTIC USE
       AIDS-Related Opportunistic Infections/DIAGNOSIS/*DRUG THERAPY/
       EPIDEMIOLOGY  Child  Drug Therapy, Combination  Human  Tuberculosis,
       Multidrug-Resistant/DIAGNOSIS/*DRUG THERAPY/  EPIDEMIOLOGY
       Tuberculosis, Pulmonary/DIAGNOSIS/*DRUG THERAPY/EPIDEMIOLOGY  United
       States/EPIDEMIOLOGY  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).