Document 0018
 DOCN  M95A0018
 TI    Sequence analysis of HIV-1 vif gene in Spanish isolates.
 DT    9510
 AU    Olivares I; Menendez-Arias L; Rodriguez-Bernabe A; Martin MJ; Dopazo J;
       Lopez-Galindez C; Centro Nacional de Biologia Celular y Retrovirus,
       Instituto; Carlos III, Majadahonda, Madrid, Spain.
 SO    Virus Genes. 1995 Feb;9(3):283-8. Unique Identifier : AIDSLINE
       MED/95320974
 AB    We have determined the nucleotide sequence of the HIV-1 vif gene in
       viruses obtained from symptomatic patients of distinct risk groups in
       Madrid. The genetic diversity among the isolates was estimated in 4.6%
       (+/- 1.4 standard deviation), a similar value to that obtained for the
       gag gene 3.9% (+/- 0.8 standard deviation) and env 4.1% (+/- 1 standard
       deviation) (Rojas et al., Virus Res 31, 331-342, 1994). Amino acid
       sequence analysis revealed the presence of hypermutable residues at
       positions 101 and 167, close to antigenically relevant sequential
       epitopes (comprising amino acids 87-94 and 172-178). Phylogenetic
       analysis supports the existence of two virus lineages circulating
       preferentially within different risk groups.
 DE    Adult  Amino Acid Sequence  Base Sequence  Blood Transfusion/ADVERSE
       EFFECTS  Comorbidity  Comparative Study  Consensus Sequence  *Genes, vif
       Homosexuality  Human  HIV Infections/CONGENITAL/EPIDEMIOLOGY/VIROLOGY
       HIV-1/*GENETICS/ISOLATION & PURIF  Infant, Newborn  Molecular Sequence
       Data  Phylogeny  Risk Factors  Sequence Alignment  Sequence Homology,
       Nucleic Acid  Spain/EPIDEMIOLOGY  Substance Abuse,
       Intravenous/EPIDEMIOLOGY  Support, Non-U.S. Gov't  Variation (Genetics)
       JOURNAL ARTICLE

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