Document 0025
 DOCN  M95A0025
 TI    Skin necrosis indicating antiphospholipid syndrome in patient with AIDS.
 DT    9510
 AU    Soweid AM; Hajjar RR; Hewan-Lowe KO; Gonzalez EB; Department of Internal
       Medicine, Emory University School of; Medicine, Atlanta, GA, USA.
 SO    South Med J. 1995 Jul;88(7):786-8. Unique Identifier : AIDSLINE
       MED/95320649
 AB    Although antiphospholipid antibodies have been detected in patients with
       human immunodeficiency virus (HIV) disease, the clinical manifestations
       of the antiphospholipid syndrome are extremely rare. We describe a woman
       with acquired immunodeficiency syndrome (AIDS) and elevated
       antiphospholipid antibodies who developed necrotic skin lesions and was
       subsequently shown to have antiphospholipid syndrome. This finding
       contradicts the general belief that such antibodies are not clinically
       significant in patients with HIV disease. We follow the report with a
       brief description of the antiphospholipid syndrome and its relation to
       AIDS.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS/IMMUNOLOGY  Adult
       Antibodies, Anticardiolipin/BLOOD  Antibodies, Antiphospholipid/BLOOD
       Antiphospholipid Syndrome/*ETIOLOGY/IMMUNOLOGY  Case Report  Female
       Human  IgG/BLOOD  Necrosis  Skin/*PATHOLOGY/ULTRASTRUCTURE  JOURNAL
       ARTICLE

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