Document 0028
 DOCN  M95A0028
 TI    Clinical brain radionuclide imaging studies.
 DT    9510
 AU    Messa C; Fazio F; Costa DC; Ell PJ; INB-CNR, University of Milan, S.
       Raffaele Institute, Italy.
 SO    Semin Nucl Med. 1995 Apr;25(2):111-43. Unique Identifier : AIDSLINE
       MED/95320562
 AB    A recent survey of the knowledge and practice of both positron-emission
       tomography (PET) and single-photon emission computed tomography (SPECT)
       of the brain among referring physicians in Europe (neurologists and
       psychiatrists) showed a disquieting lack of knowledge of the potential
       of these methodologies in the investigation and management of patients
       of their own specialities. The need to bring the knowledge of the
       potential of these techniques to the practicing physicians is paramount.
       It is imperative that the methodologies and concepts that preside over
       the application of these techniques in neurology and psychiatry must
       become more uniform if an impact is to be felt at a clinical level.
       There is clear improvement in the instrumentation available with the new
       state-of-the-art tomographic devices and with the development of new
       technetium-based radiopharmaceuticals for the study of cerebral
       perfusion. The constant progress made with ligands that permit the study
       of neurotransmission, tumor metabolism, and turnover do expand our
       capability to improve the knowledge concerning neurophysiology,
       neuropathology, and neuropharmacology of a variety of disease states.
       PET and SPECT will be progressively included in protocols aimed at
       stratifying patients with dementia, monitoring therapeutic trials, and
       improving our ability to determine outcome. Clinical usefulness of PET
       and SPECT begin to emerge in cerebral vascular disease, in the
       identification of cerebral death, in epilepsy, in cerebral trauma, in
       the investigation of HIV-positive patients with cerebral involvement,
       and in the monitoring of tumor recurrence and postirradiation damage.
       This review article outlines a current perspective of SPECT and PET as
       practiced in Europe, its potential, and its limitations.
 DE    Brain/*RADIONUCLIDE IMAGING  Brain Diseases/*RADIONUCLIDE IMAGING
       Female  Human  Male  Mental Disorders/RADIONUCLIDE IMAGING  *Radioactive
       Tracers  *Tomography, Emission-Computed  *Tomography, Emission-Computed,
       Single-Photon  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).