Document 0033
 DOCN  M95A0033
 TI    Management of human immunodeficiency virus-associated malignancies.
 DT    9510
 AU    Conant MA; University of California Medical Center, San Francisco, USA.
 SO    Recent Results Cancer Res. 1995;139:423-32. Unique Identifier : AIDSLINE
       MED/95320453
 AB    A number of malignancies which have been seen with other
       immunodeficiency diseases have appeared in patients immunosuppressed by
       the human immunodeficiency virus (HIV) infection. These include Kaposi's
       sarcoma, lymphomas, superficially spreading basal cell carcinomas, and
       squamous cell carcinomas. The fact that Kaposi's sarcoma is the most
       common of these malignancies and is seen almost exclusively among
       homosexual men remains an enigma. The dermatological treatment of
       Kaposi's sarcoma includes observation, surgical excision, radiation
       therapy, interlesional chemotherapy, and topical liquid nitrogen. When
       the disease becomes more aggressive, systemic chemotherapy, using a
       combination of chemotherapeutic agents, will often slow disease
       progression. It is essential that the chemotherapy be given in a dose
       that will slow the course of the malignancy, but will not further
       immunosuppress the patient. The treatment of lymphomas in HIV-infected
       patients has been less than satisfactory, with a high mortality rate.
       Aggressive therapy of these lymphomas using combination therapy has been
       the most successful in increasing survival.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS  Antineoplastic
       Agents/THERAPEUTIC USE  Biological Response Modifiers/THERAPEUTIC USE
       Carcinoma, Basal Cell/COMPLICATIONS/THERAPY  Carcinoma, Squamous
       Cell/COMPLICATIONS/THERAPY  Combined Modality Therapy  Female  Human
       Immunocompromised Host  Immunotherapy  Injections, Intralesional
       Lymphoma, AIDS-Related/DRUG THERAPY/MORTALITY/*THERAPY  Male
       Melanoma/COMPLICATIONS  Sarcoma, Kaposi's/ETIOLOGY/*THERAPY  Sezary
       Syndrome/COMPLICATIONS  Skin Neoplasms/ETIOLOGY/*THERAPY
       Vinblastine/ADMINISTRATION & DOSAGE/THERAPEUTIC USE  JOURNAL ARTICLE
       REVIEW  REVIEW, TUTORIAL

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