Document 0036
 DOCN  M95A0036
 TI    New perspectives in experimental and clinical research for cutaneous T
       cell lymphomas.
 DT    9510
 AU    Burg G; Haffner A; Boni R; Dommann S; Dummer R; Department of
       Dermatology, University of Zurich Medical School,; Switzerland.
 SO    Recent Results Cancer Res. 1995;139:225-37. Unique Identifier : AIDSLINE
       MED/95320435
 AB    Cutaneous T cell lymphomas (CTCL) are lymphoproliferative disorders,
       which can be classified by an adaptation of the Kiel classification. The
       most common CTCL, Mycosis fungoides (MF) and Sezary syndrome (SS), are
       monoclonal T helper memory lymphomas. They belong to the group of
       peripheral T cell lymphomas. However, CTCL includes other disease
       entities such as granulomatous slack skin, pagetoid reticulosis, and
       lipotropic CTCL. Polymerase chain reaction of the T cell receptor
       (TCR)-gamma and screening of the PCR products for sequence-specific
       mobility in acrylamide gels has increased the detection limit for clonal
       T cells in the skin. This method will help to define the relationship of
       CTCL to other lymphoproliferative disorders and may contribute to the
       early diagnosis of CTCL. In SS, the malignant CTCL clone secretes a T
       helper-2 cytokine pattern, which might be responsible for the systemic
       immunosuppression in CTCL patients. New treatment modalities (IL-12)
       might correct these immunologic abnormalities. Cutaneous B cell
       lymphomas mostly are follicular center cell derived and usually have a
       good prognosis. Therapy of cutaneous lymphomas should take into account
       prognostic factors, the most reliable of which in CTCL is the tumor mass
       expressed by the tumor burden index.
 DE    Cytokines/PHYSIOLOGY  Human  HTLV-I/ISOLATION & PURIF/PATHOGENICITY
       HTLV-I Infections  Lymphoma, B-Cell/CLASSIFICATION  *Lymphoma, T-Cell,
       Cutaneous/CLASSIFICATION/DIAGNOSIS/ETIOLOGY/  PATHOLOGY/THERAPY  *Skin
       Neoplasms/CLASSIFICATION/DIAGNOSIS/ETIOLOGY/PATHOLOGY/  THERAPY
       T-Lymphocyte Subsets/PATHOLOGY  T-Lymphocytes, Helper-Inducer/SECRETION
       JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

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