Document 0065
 DOCN  M95A0065
 TI    Sunlight induced progression of AIDS.
 DT    9510
 AU    Vincek V; Department of Microbiology and Immunology, University of
       Miami; School of Medicine, FL 33101, USA.
 SO    Med Hypotheses. 1995 Feb;44(2):119-23. Unique Identifier : AIDSLINE
       MED/95319349
 AB    Ultraviolet B (UVB) radiation in sunlight damages the cutaneous immune
       system of individuals primarily by converting trans-urocanic acid (UCA)
       to its cis isoform which in turn instigates excessive local, and
       eventually systemic, levels of tumor necrosis factor-alpha (TNF alpha).
       UVB radiation and TNF alpha have been found to activate HIV from the
       latent state, and TNF alpha has been implicated in the pathogenesis of
       several manifestations of the acquired immune deficiency syndrome
       (AIDS). We hypothesize that the immunosuppressant properties of TNF
       alpha and cis-UCA, released by intense sun exposure, can accelerate the
       onset and progression of AIDS in HIV-infected individuals.
 DE    Acquired Immunodeficiency Syndrome/*PHYSIOPATHOLOGY  Animal  Disease
       Progression  Epidermis/*IMMUNOLOGY/RADIATION EFFECTS  Human  HIV/GROWTH
       & DEVELOPMENT  Immune Tolerance/RADIATION EFFECTS
       Immunocompetence/RADIATION EFFECTS  Mice  Models, Immunological
       Prostaglandins E/BIOSYNTHESIS  Sunlight/*ADVERSE EFFECTS  Support,
       Non-U.S. Gov't  Th2 Cells/IMMUNOLOGY  Tumor Necrosis Factor/*SECRETION
       Ultraviolet Rays/*ADVERSE EFFECTS  Urocanic Acid/RADIATION EFFECTS
       Virus Activation  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

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