Document 0067
 DOCN  M95A0067
 TI    The expression of adhesion molecules, including CD11a and CD11b, on the
       human T lymphocyte surface membrane in patients with bronchial asthma.
 DT    9510
 AU    Sumida S; Department of Medicine, Kurume University School of Medicine,;
       Japan.
 SO    Kurume Med J. 1995;42(1):21-32. Unique Identifier : AIDSLINE
       MED/95319116
 AB    The beta-2 integrin consists of lymphocyte function-antigen-1 (LFA-1,
       CD11a/CD18) which binds to the major ligand intracellular adhesion
       molecules 1 and 2 (ICAM-1 and ICAM-2), Mac-1 (CD11b/CD18, ligand iC3b)
       and p150,95 (CD11c/CD18, ligand iC3b). These molecules function not only
       as adhesion molecules but as signal transduction agents. To investigate
       the expression of an integrin family in asthma, lymphocyte subsets were
       assessed using bronchoalveolar lavage fluid (BALF) cells obtained from
       asthma patients. The relationship between the integrins and lymphocyte
       subpopulations and their activation state in the BALF was analyzed using
       two-color flow cytometry in 15 subjects with asthma and in 13 control
       subjects with chronic bronchitis. The absolute number of CD11a+CD4+
       lymphocytes was significantly greater in the asthmatics than in the
       nonsmoking subjects with chronic bronchitis. In the asthmatics, the
       expression of the CD11a+CD4+ lymphocytes was significantly higher than
       the expression of CD11a+CD8+ lymphocytes. The CD2+ lymphocytes had a
       significant positive regression with the CD11a+CD4+ lymphocytes in the
       asthmatics. These findings indicate that the CD11a+ antigen is mainly
       located on the CD4+ lymphocytes in asthmatics, and that the subset of
       CD11a lymphocytes with the CD4+ antigen increases as the absolute number
       of T lymphocytes increases. Analysis of BALF revealed the representation
       of integrins for the ongoing bronchial transfer of information, and may
       provide an approach to obtain evidence about the inflammatory processes
       on the surface of the bronchioles in asthma.
 DE    Adult  Aged  Antigens, CD11/*ANALYSIS
       Asthma/*IMMUNOLOGY/PHYSIOPATHOLOGY  Bronchoalveolar Lavage
       Fluid/CYTOLOGY  CD4-CD8 Ratio  Female  Human  Lung/PHYSIOPATHOLOGY
       Lymphocyte Subsets  Male  Middle Age  Regression Analysis
       T-Lymphocytes/*IMMUNOLOGY  JOURNAL ARTICLE

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