Document 0095
 DOCN  M95A0095
 TI    A soluble form of tumour necrosis factor receptor in cerebrospinal fluid
       and serum of HTLV-I-associated myelopathy and other neurological
       diseases.
 DT    9510
 AU    Puccioni-Sohler M; Rieckmann P; Kitze B; Lange P; Albrecht M;
       Felgenhauer K; Klinik und Poliklinik fur Neurologie,
       Georg-August-Universitat,; Gottingen, Germany.
 SO    J Neurol. 1995 Mar;242(4):239-42. Unique Identifier : AIDSLINE
       MED/95318750
 AB    Paired samples of cerebrospinal fluid (CSF) and serum from 17 patients
       with human T-cell lymphotrophic virus I (HTLV-I)-associated myelopathy,
       5 patients with multiple sclerosis and 11 controls with non-inflammatory
       disorders (migraine, idiopathic epilepsy and myelopathy of unknown
       aetiology) were examined by enzyme-linked immunosorbent assay for the
       presence of the 60-kDa soluble form of tumour necrosis factor receptor
       (sTNF-R). The results were compared with blood-CSF barrier function,
       cell count and the intrathecal synthesis of HTLV-I antibodies. No
       correlation could be demonstrated. High levels of sTNF-R were found in
       CSF of patients with HTLV-I-associated myelopathy and multiple
       sclerosis. In addition, intrathecal sTNF-R was also detected in the
       patients with non-inflammatory diseases, indicating that sTNF-R is
       definitively a normal constituent of CSF.
 DE    *Blood-Brain Barrier  Cell Count  Central Nervous System
       Diseases/*BLOOD/*CEREBROSPINAL FLUID  Comparative Study  Human  HTLV-I
       Antibodies/BIOSYNTHESIS/CEREBROSPINAL FLUID  Multiple
       Sclerosis/*BLOOD/*CEREBROSPINAL FLUID  Paraparesis, Tropical
       Spastic/*BLOOD/*CEREBROSPINAL FLUID  Receptors, Tumor Necrosis
       Factor/*ANALYSIS  Solubility  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).