Document 0100
 DOCN  M95A0100
 TI    The predictive value of T cell function in vitro and pre-AIDS zidovudine
       use for survival after AIDS diagnosis in a cohort of homosexual men in
       Amsterdam.
 DT    9510
 AU    Bindels PJ; Krol A; Roos M; Veenstra J; van den Hoek JA; Miedema F;
       Coutinho RA; Department of Public Health, Amsterdam, Netherlands.
 SO    J Infect Dis. 1995 Jul;172(1):97-104. Unique Identifier : AIDSLINE
       MED/95318564
 AB    The best independent predictors of survival after AIDS diagnosis were
       determined in 160 homosexual men from the Amsterdam Cohort Study (1987
       CDC case definition). In a Cox model, all pre-AIDS laboratory markers
       gathered during follow-up in the study did not independently predict
       survival after AIDS. A second analysis, using data available only at
       AIDS diagnosis, revealed that T cell reactivity after stimulation with
       phytohemagglutinin and monoclonal CD3 antibodies and the CD4+ cell count
       at diagnosis were independent predictors of survival. In an
       interval-based Cox model, the predictive value of pre-AIDS zidovudine
       use was determined. One year after AIDS diagnosis, participants with
       pre-AIDS zidovudine use had a worse survival probability (relative
       hazard = 3.99). In conclusion, the survival probability of homosexual
       men with AIDS can be estimate adequately using information obtained at
       clinical AIDS diagnosis. Analysis revealed the important predictive
       value of T cell function tests in vitro.
 DE    Acquired Immunodeficiency Syndrome/DRUG THERAPY/MORTALITY/
       *PHYSIOPATHOLOGY  Adult  Age Factors  Analysis of Variance  Antigens,
       CD/ANALYSIS  Biological Markers  Cells, Cultured  Cohort Studies
       Comparative Study  CD4-CD8 Ratio  Follow-Up Studies  *Homosexuality,
       Male  Human  HIV/ISOLATION & PURIF  HIV Seropositivity/*DRUG
       THERAPY/*IMMUNOLOGY/MORTALITY  *Lymphocyte Transformation  Male
       Multivariate Analysis  Netherlands  Predictive Value of Tests  Prognosis
       Prospective Studies  Support, Non-U.S. Gov't  Survival Analysis
       T-Lymphocyte Subsets/*IMMUNOLOGY  T-Lymphocytes/*IMMUNOLOGY  Time
       Factors  Zidovudine/*THERAPEUTIC USE  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).