Document 0102
 DOCN  M95A0102
 TI    In vitro T cell function, delayed-type hypersensitivity skin testing,
       and CD4+ T cell subset phenotyping independently predict survival time
       in patients infected with human immunodeficiency virus.
 DT    9510
 AU    Dolan MJ; Clerici M; Blatt SP; Hendrix CW; Melcher GP; Boswell RN;
       Freeman TM; Ward W; Hensley R; Shearer GM; Department of Infectious
       Diseases, Wilford Hall Medical Center,; Lackland Air Force Base, TX
       78236-5300, USA.
 SO    J Infect Dis. 1995 Jul;172(1):79-87. Unique Identifier : AIDSLINE
       MED/95318562
 AB    Human immunodeficiency virus type 1 (HIV-1)-infected patients (n = 335)
       in the US Air Force HIV Natural History Program were followed for 3
       years (mean) after skin testing, immunophenotyping of CD4+ cell subsets,
       and measurement of in vitro interleukin-2 production after stimulation
       by phytohemagglutinin, alloantigens, tetanus toxoid, and influenza A
       virus. The T cell functional assay predicted survival time (P < .001)
       and time for progression to AIDS (P = .014). Skin testing for tetanus,
       mumps, and Candida antigen and the total number of positive tests (P <
       .001 for each) stratified patients for survival time. In a multivariable
       proportional hazards model, the T cell functional assay (P = .008), the
       absolute number of CD4+ T cells (P = .001), the percentage of CD4+ CD29+
       cells (P = .06), and the number of reactive skin tests (P < .001)
       predicted survival time. Thus, cellular immune functional tests have
       significant predictive value for survival time in HIV-1-infected
       patients independent of CD4+ cell count.
 DE    Acquired Immunodeficiency Syndrome/IMMUNOLOGY/MORTALITY/
       *PHYSIOPATHOLOGY  Adult  Comparative Study  CD4 Lymphocyte Count
       CD4-Positive T-Lymphocytes/*IMMUNOLOGY  Female  Human
       *Hypersensitivity, Delayed  HIV Infections/*IMMUNOLOGY/*MORTALITY
       Immunity, Cellular  Male  Middle Age  Military Personnel  Multivariate
       Analysis  Predictive Value of Tests  Prognosis  Proportional Hazards
       Models  Skin Tests  Support, Non-U.S. Gov't  Support, U.S. Gov't,
       Non-P.H.S.  Support, U.S. Gov't, P.H.S.  Survival Rate
       T-Lymphocytes/*IMMUNOLOGY  Time Factors  United States  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).