Document 0106
 DOCN  M95A0106
 TI    Leishmania-human immunodeficiency virus coinfection in the Mediterranean
       basin: isoenzymatic characterization of 100 isolates of the Leishmania
       infantum complex.
 DT    9510
 AU    Pratlong F; Dedet JP; Marty P; Portus M; Deniau M; Dereure J; Abranches
       P; Reynes J; Martini A; Lefebvre M; et al; Laboratoire d'Ecologie
       Medicale et Pathologie Parasitaire,; Faculte de Medecine, Centre
       Hospitalo-Universitaire,; Montpellier, France.
 SO    J Infect Dis. 1995 Jul;172(1):323-6. Unique Identifier : AIDSLINE
       MED/95318556
 AB    Isoenzymatic characterization was done on 100 isolates obtained from
       visceral leishmaniasis (VL) patients coinfected with human
       immunodeficiency virus (HIV); isolates had been received between 1986
       and 1993 at the International Leishmania Cryobank and Identification
       Centre in Montpellier, France. Electrophoresis was done with 15
       isoenzymes using the starch gel technique combined, where appropriate,
       with isoelectrofocusing. Nine Leishmania infantum zymodemes were
       identified; L. infantum zymodeme MON-1, the most common parasite of
       human VL in the Mediterranean basin, was the most frequent in
       coinfections. It could also occasionally be responsible for localized
       cutaneous leishmaniasis lesions. Several dermotropic zymodemes, which
       were responsible for localized cutaneous leishmaniasis in
       immunocompetent patients, caused VL in HIV-positive patients. In
       addition, in 10 patients, a second isolate obtained during relapses
       occurring between 1.5 and 9.0 months after treatment was identical to
       the original isolate.
 DE    Animal  Comparative Study  Electrophoresis, Starch Gel  France  Human
       HIV Infections/*COMPLICATIONS/DIAGNOSIS  HIV Seropositivity  Isoelectric
       Focusing  Isoenzymes/*ANALYSIS  *Leishmania
       infantum/ENZYMOLOGY/ISOLATION & PURIF  Leishmaniasis,
       Mucocutaneous/*COMPLICATIONS/DIAGNOSIS  Portugal  Spain  Support,
       Non-U.S. Gov't  JOURNAL ARTICLE

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