Document 0109
 DOCN  M95A0109
 TI    Transplantation of skin from human immunodeficiency virus type
       1-transgenic mice to normal congenic mice results in graft rejection.
 DT    9510
 AU    Dumois JA; VanderVegt FP; Kopp JB; Marinos NJ; Rooney JF; Notkins AL;
       Laboratory of Oral Medicine, National Institute of Dental; Research,
       National Institutes of Health, Bethesda, MD 20892-4322,; USA.
 SO    J Infect Dis. 1995 Jul;172(1):232-4. Unique Identifier : AIDSLINE
       MED/95318530
 AB    Skin from mice transgenic (Tg) for part of the human immunodeficiency
       virus type 1 (HIV-1) genome was transplanted onto normal mice of the
       same strain. All Tg grafts were rejected within 29 days. In contrast,
       skin from normal mice that was transplanted to HIV-1-Tg recipients
       remained viable for > 67 days. Histologic examination of Tg grafts on
       normal mice showed evidence of monocytic infiltrates. Monocytic
       infiltrates were not observed, however, when either normal or Tg skin
       was transplanted onto Tg mice. Immunohistologic staining verified the
       presence of gp120 protein expression in the Tg-transplanted skin but not
       in adjacent normal skin. It is concluded that the Tg mice are
       immunologically tolerant to the HIV-1 gene products they express.
 DE    Animal  Comparative Study  Gene Deletion  Genome, Viral  Graft
       Rejection/*IMMUNOLOGY/PATHOLOGY  *Graft Survival  HIV Envelope Protein
       gp120/ANALYSIS/*BIOSYNTHESIS  HIV-1/*GENETICS/METABOLISM  Mice  Mice,
       SCID  Mice, Transgenic  Skin Transplantation/*IMMUNOLOGY/PATHOLOGY  Time
       Factors  Transplantation, Homologous  JOURNAL ARTICLE

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