Document 0110
 DOCN  M95A0110
 TI    Human immunodeficiency virus (HIV) type 1 infection status and in vitro
       susceptibility to HIV infection among high-risk HIV-1-seronegative
       hemophiliacs.
 DT    9510
 AU    Lederman MM; Jackson JB; Kroner BL; White GC 3rd; Eyster ME; Aledort LM;
       Hilgartner MW; Kessler CM; Cohen AR; Kiger KP; et al; Case Western
       Reserve University School of Medicine, Ohio, USA.
 SO    J Infect Dis. 1995 Jul;172(1):228-31. Unique Identifier : AIDSLINE
       MED/95318529
 AB    Blood samples were obtained from 16 hemophiliacs who had a 50%-94%
       defined risk of human immunodeficiency virus (HIV) type 1 infection on
       the basis of treatment history and from 14 controls not at risk for HIV
       infection. HIV-1 was not detected in any of 12 patient samples by
       cocultivation nor in 14 patient samples by the polymerase chain
       reaction. Peripheral blood cells from 7 seronegative hemophiliacs at
       highest risk of seroconversion (94%) were less susceptible to HIV-1
       infection in vitro than were cells from healthy controls (P < .025,
       one-tailed Wilcoxon rank sum test). In contrast, the susceptibility to
       HIV-1 infection of lymphocytes from 6 seronegative hemophiliacs at
       moderate risk (50%-56%) of seroconversion did not differ from that of
       cells from controls or from high-risk hemophiliacs. Therefore, prolonged
       periods of seronegative HIV-1 infection are not common in this high-risk
       population. In addition, among hemophiliacs there may exist
       heterogeneity in susceptibility to HIV-1 infection in vitro and in vivo.
 DE    Adult  Comparative Study  CD4 Lymphocyte Count  CD8-Positive
       T-Lymphocytes/IMMUNOLOGY  Disease Susceptibility  Factor IX/ANALYSIS
       Factor VIII/ANALYSIS  Hemophilia/BLOOD/*COMPLICATIONS/IMMUNOLOGY  Human
       HIV Infections/*EPIDEMIOLOGY/TRANSMISSION  *HIV Seronegativity  HIV
       Seropositivity/*IMMUNOLOGY  *HIV-1/GENETICS/ISOLATION & PURIF
       Lymphocyte Count  Male  Polymerase Chain Reaction  Risk Factors
       Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).