Document 0114
 DOCN  M95A0114
 TI    Massive activation of immune cells with an intact T cell repertoire in
       acute human immunodeficiency virus syndrome.
 DT    9510
 AU    Cossarizza A; Ortolani C; Mussini C; Borghi V; Guaraldi G; Mongiardo N;
       Bellesia E; Franceschini MG; De Rienzo B; Franceschi C; Department of
       Biomedical Sciences, University of Modena School of; Medicine, Italy.
 SO    J Infect Dis. 1995 Jul;172(1):105-12. Unique Identifier : AIDSLINE
       MED/95318508
 AB    In 8 patients with symptomatic, acute primary infection with human
       immunodeficiency virus (HIV), a dramatic and persistent decrease in CD4+
       lymphocytes was seen, accompanied by a marked increase in
       activated/memory CD8+ T cells (CD38+, CD45R0+, HLA-DR+, with high
       amounts of cell adhesion molecules), which represented most circulating
       lymphocytes, but no gross alterations in V beta T cell repertoire.
       Extremely high plasma levels of proinflammatory cytokines were observed.
       Three patients were followed for 2-3 years: The number of CD4+ cells,
       extremely low at first, increased significantly in a few months but
       decreased rapidly after a short stable period. Cytotoxic T lymphocytes
       bearing markers of immunologic activation/memory could play an important
       role in the earliest phases of the disease. It remains to be established
       how such a dramatic onset could determine the rapid progression of the
       infection that seems characteristic of patients with acute HIV syndrome.
 DE    Acquired Immunodeficiency Syndrome/*IMMUNOLOGY  Adult  Antigens,
       CD/BLOOD  Biological Markers  Comparative Study  CD4-Positive
       T-Lymphocytes/IMMUNOLOGY  CD8-Positive T-Lymphocytes/IMMUNOLOGY  Female
       Fluorescent Antibody Technique  Human  HIV Antibodies/BLOOD  HIV Core
       Protein p24/BLOOD  HIV Seropositivity/IMMUNOLOGY  *HIV-1  HLA-DR
       Antigens/BLOOD  Immunophenotyping  *Lymphocyte Transformation  Male
       Receptors, Antigen, T-Cell, alpha-beta/ANALYSIS  Reference Values
       Support, Non-U.S. Gov't  T-Lymphocytes/*IMMUNOLOGY  JOURNAL ARTICLE

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