Document 0117
 DOCN  M95A0117
 TI    Increased levels of soluble vascular cell adhesion molecule-1 (VCAM-1)
       in the cerebrospinal fluid and sera of patients with multiple sclerosis
       and human T lymphotropic virus type-1-associated myelopathy.
 DT    9510
 AU    Matsuda M; Tsukada N; Miyagi K; Yanagisawa N; Department of Medicine
       (Neurology), Shinshu University School of; Medicine, Matsumoto, Japan.
 SO    J Neuroimmunol. 1995 Jun;59(1-2):35-40. Unique Identifier : AIDSLINE
       MED/95318224
 AB    We evaluated the relationship between the soluble form of vascular cell
       adhesion molecule-1 (sVCAM-1) and disease activity in patients with
       multiple sclerosis (MS) or with human T lymphotropic virus type
       1-associated myelopathy (HAM), and measured levels of sVCAM-1 in their
       cerebrospinal fluid (CSF) and sera. Serum and CSF levels of sVCAM-1 were
       significantly increased in patients with acute relapsing MS during an
       exacerbation (P < 0.01 and P < 0.001), as well as in chronic progressive
       MS (P < 0.05 and P < 0.001), compared with healthy individuals and
       patients with other neurological diseases, respectively. Patients with
       acute relapsing MS during an exacerbation also exhibited significantly
       higher serum and CSF levels of sVCAM-1 vs. patients with acute relapsing
       MS in remission (P < 0.001). Significantly higher serum levels of
       sVCAM-1 were observed in patients with HAM vs. either healthy
       individuals (P < 0.01) or non-HAM carriers (P < 0.01). These results
       suggest that the determination of sVCAM-1 in the sera and CSF may be
       useful in monitoring the activity of MS and HAM.
 DE    Adult  Aged  Cell Adhesion Molecules/*BLOOD/*CEREBROSPINAL FLUID  Female
       Human  Intercellular Adhesion Molecule-1/ANALYSIS  Male  Middle Age
       Multiple Sclerosis/*METABOLISM  Paraparesis, Tropical
       Spastic/*METABOLISM  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).