Document 0118
 DOCN  M95A0118
 TI    Psychological stress and immunological responsiveness in normally
       cycling, follicular-stage women.
 DT    9510
 AU    Caggiula AR; McAllister CG; Matthews KA; Berga SL; Owens JF; Miller AL;
       Department of Psychology, University of Pittsburgh, PA 15260,; USA.
 SO    J Neuroimmunol. 1995 Jun;59(1-2):103-11. Unique Identifier : AIDSLINE
       MED/95318211
 AB    Nineteen women in the follicular stage of their menstrual cycles were
       assessed for immunological responsiveness to a 50-min series of three
       psychological tasks which reliably elicit cardiovascular and
       neuroendocrine stress responses. Ten follicular-stage women not
       subjected to stress served as controls. Stress decreased lymphocyte
       responsiveness to PHA and PWM, percent of CD4+ cells and the ratio of
       CD4+/CD8+ cells. Conversely, stress increased natural killer cell number
       and cytolytic activity, white blood cell, lymphocyte, T and B cell
       count. Except for natural killer cell number, none of these changes was
       exhibited by controls. Most of these stress responses are similar to
       those reported for men and form the basis for a continuing study of the
       effects of reproductive hormones and stress on cardiovascular and
       immunological function in women.
 DE    Adult  CD4-CD8 Ratio  Female  *Follicular Phase  Human  Killer Cells,
       Natural/IMMUNOLOGY  Lymphocyte Transformation  Stress,
       Psychological/*IMMUNOLOGY  Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).