Document 0121
 DOCN  M95A0121
 TI    gp180, a host cell glycoprotein that binds duck hepatitis B virus
       particles, is encoded by a member of the carboxypeptidase gene family.
 DT    9510
 AU    Kuroki K; Eng F; Ishikawa T; Turck C; Harada F; Ganem D; Department of
       Biophysics, Kanazawa University, Ishikawa, Japan.
 SO    J Biol Chem. 1995 Jun 23;270(25):15022-8. Unique Identifier : AIDSLINE
       GENBANK/U25126
 AB    Duck hepatitis B virus particles bearing the L and S envelope proteins
       bind a cellular glycoprotein of 180 kDa (gp180) with high affinity and
       specificity. Binding is mediated by the pre-S region of the L protein
       and is blocked by neutralizing but not by non-neutralizing monoclonal
       antibodies to the virus. These and other properties have suggested that
       gp180 may be a component of the viral entry machinery. Here we report
       the purification of gp180 from duck liver and the isolation and
       characterization of cDNA encoding it. DNA sequence analysis of this cDNA
       indicates that gp180 is a novel member of the basic carboxypeptidase
       gene family.
 DE    Amino Acid Sequence  Animal  Base Sequence
       Carboxypeptidases/BIOSYNTHESIS/*GENETICS/*METABOLISM  Cell Line
       Cloning, Molecular  Comparative Study  Ducks  Gene Products,
       env/METABOLISM  *Genes, Reiterated  Hepatitis B Virus, Duck/*PHYSIOLOGY
       Human  Liver/*METABOLISM/*VIROLOGY  Membrane
       Glycoproteins/BIOSYNTHESIS/*GENETICS/*METABOLISM  Molecular Sequence
       Data  Oligodeoxyribonucleotides  Peptide Fragments/CHEMISTRY/ISOLATION &
       PURIF  Restriction Mapping  Sequence Homology, Amino Acid  Support,
       Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.  Transfection  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).