Document 0135
 DOCN  M95A0135
 TI    The history of live bacterial vaccines.
 DT    9510
 AU    Lindberg AA; Lederle-Praxis Biologicals, Wayne, NJ, USA.
 SO    Dev Biol Stand. 1995;84:211-9. Unique Identifier : AIDSLINE MED/95317474
 AB    Recent developments have made it possible to construct non-reverting
       live bacterial vaccine candidates with defined deletions of two or more
       genes. Such vaccines have proven safe and immunogenic in human
       volunteers. Since the virulent parent strains are only pathogenic to man
       (S. typhi, S. flexneri, and V. cholerae), they pose no threat to the
       environment. Besides holding promise as efficacious vaccines for
       protection against typhoid fever, bacillary dysentery and cholera, the
       attenuated strains are well suited as vectors for delivery of
       heterologous antigenic epitopes from micro-organisms such as
       Helicobacter pylori, Neisseira gonorrhoeae, rotavirus, HIV and many
       others. Instead of using a virulent parent bacterium as the starting
       organism for making a vector, attempts have recently been made to employ
       non-pathogenic bacteria of the normal human flora, such as Streptococcus
       gordonii for delivery of foreign antigens. At present, the feasibility
       of this approach for human beings remains to be proven.
 DE    Animal  Bacterial Infections/HISTORY/PREVENTION & CONTROL  Bacterial
       Vaccines/GENETICS/*HISTORY  Genetic Vectors  History of Medicine, 19th
       Cent.  History of Medicine, 20th Cent.  Human  Mutation  Salmonella
       typhi/GENETICS/IMMUNOLOGY  Shigella/GENETICS/IMMUNOLOGY  Vaccines,
       Attenuated/HISTORY  Vaccines, Synthetic/HISTORY  Vibrio
       cholerae/IMMUNOLOGY  HISTORICAL ARTICLE  JOURNAL ARTICLE

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       protected by Copyright Law (Title 17, U.S.Code).