Document 0138
 DOCN  M95A0138
 TI    A kinetic model for comparing proteolytic processing activity and
       inhibitor resistance potential of mutant HIV-1 proteases.
 DT    9510
 AU    Tang J; Hartsuck JA; Protein Studies Program, Oklahoma Medical Research
       Foundation,; Oklahoma City 73104, USA.
 SO    FEBS Lett. 1995 Jun 26;367(2):112-6. Unique Identifier : AIDSLINE
       MED/95317407
 AB    A kinetic model is presented for the comparison of potential proteolytic
       processing activities of wild-type and mutant human immunodeficiency
       virus proteases in the presence and absence of protease inhibitors. The
       protease processing of gag substrate in the immature virions is assessed
       by the kinetic parameters, kcat, Km and Ki. The relationship of the
       estimated potential processing activities to the viability of the HIV
       mutants and their tendencies to resist inhibitors also are discussed. A
       fully developed model has the potential to stimulate the results of
       inhibitor resistance either in vivo or in cell culture.
 DE    Drug Resistance, Microbial  Gene Products, gag/METABOLISM  HIV
       Protease/CHEMISTRY/GENETICS/*METABOLISM  HIV Protease
       Inhibitors/METABOLISM/*PHARMACOLOGY  HIV-1/DRUG
       EFFECTS/*ENZYMOLOGY/GENETICS  Kinetics  Mutation  Protein
       Precursors/METABOLISM  *Protein Processing, Post-Translational  Support,
       U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).