Document 0143
 DOCN  M95A0143
 TI    The management of sinusitis in patients infected with the human
       immunodeficiency virus (HIV).
 DT    9510
 AU    Tami TA; Department of Otolaryngology-Head and Neck Surgery, University
       of; Cincinnati, Ohio, USA.
 SO    Ear Nose Throat J. 1995 May;74(5):360-3. Unique Identifier : AIDSLINE
       MED/95317220
 AB    As the Human Immunodeficiency Virus (HIV) has extended its influence
       across the United States, otolaryngologists have been increasingly
       called upon to manage its various head and neck manifestations.
       Sinusitis is a very prevalent, yet difficult, management problem in this
       patient population. The pathophysiology of sinusitis in this setting
       relates to altered helper T-lymphocyte function, an abnormal
       inflammatory response as well as increased IgE-mediated inflammation.
       Chronic HIV-related sinusitis is often due to Pseudomonas aeruginosa,
       Staphylococcus aureus, or anaerobic bacteria, and empiric antibiotic
       therapy must include these potential pathogens. Early cultures can
       facilitate organism-specific antibiotic therapy. Aggressive treatment
       with decongestants, topical nasal steroids, mucoevacuants and
       occasionally antihistamines should be included at maximal tolerated
       doses. When medical therapy fails, surgical drainage can be a safe and
       effective management option. Appropriately directed medical, and
       occasionally surgical, therapy can lead to a dramatic clinical response
       and provide an improved quality of life in this patient population.
 DE    Antigens, CD  AIDS-Related Opportunistic Infections/COMPLICATIONS
       Disease Transmission, Patient-to-Professional  Drainage  Drug Therapy
       Human  HIV Seropositivity/*COMPLICATIONS  Sinusitis/DRUG
       THERAPY/*ETIOLOGY/SURGERY  T-Lymphocytes  JOURNAL ARTICLE  REVIEW
       REVIEW, TUTORIAL

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       protected by Copyright Law (Title 17, U.S.Code).