Document 0150
 DOCN  M95A0150
 TI    Adherence to zidovudine (AZT) among HIV-infected methadone patients: a
       pilot study of supervised therapy and dispensing compared to usual care.
 DT    9510
 AU    Wall TL; Sorensen JL; Batki SL; Delucchi KL; London JA; Chesney MA;
       University of California, San Francisco, San Francisco General; Hospital
       94110, USA.
 SO    Drug Alcohol Depend. 1995 Mar;37(3):261-9. Unique Identifier : AIDSLINE
       MED/95317197
 AB    Twenty-seven HIV-infected methadone maintenance patients who
       demonstrated problems adhering to zidovudine (AZT) were randomly
       assigned to a group that received eight weeks of weekday supervised
       therapy and dispensing of AZT or a group that received usual care of the
       clinic. Adherence was assessed by self-report, erythrocyte mean
       corpuscular volume (MCV), Medication Event Monitoring Systems (MEMS),
       and pill counts. Subjects in the intervention group demonstrated
       significantly higher MCV levels during the intervention period than
       usual care subjects, with similar but non-significant trends for the
       three other adherence measures. MEMS percent indicated significant group
       differences on weekdays, but not weekend days. There were no differences
       at a one-month follow-up. Results suggest supervised therapy and
       dispensing may be an effective strategy for improving AZT adherence, but
       only while provided. Further research is needed to establish the effects
       of larger and longer lasting interventions.
 DE    Adult  CD4 Lymphocyte Count/DRUG EFFECTS  Drug Monitoring  Female
       Follow-Up Studies  Human  HIV Seropositivity/*DRUG THERAPY/PSYCHOLOGY
       Male  Methadone/*ADMINISTRATION & DOSAGE  Middle Age  Nurse-Patient
       Relations  *Patient Care Team  Patient Education  Pilot Projects
       Substance Abuse, Intravenous/COMPLICATIONS/PSYCHOLOGY/  *REHABILITATION
       Support, Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.  Treatment
       Refusal/*PSYCHOLOGY  Zidovudine/*ADMINISTRATION & DOSAGE  CLINICAL TRIAL
       JOURNAL ARTICLE  RANDOMIZED CONTROLLED TRIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).