Document 0161
 DOCN  M95A0161
 TI    In the absence of a CD40 signal, B cells are tolerogenic.
 DT    9510
 AU    Buhlmann JE; Foy TM; Aruffo A; Crassi KM; Ledbetter JA; Green WR; Xu JC;
       Shultz LD; Roopesian D; Flavell RA; et al; Department of Microbiology,
       Dartmouth Medical School, Lebanon,; New Hampshire 03756, USA.
 SO    Immunity. 1995 Jun;2(6):645-53. Unique Identifier : AIDSLINE
       MED/95316720
 AB    When B cells are deprived of signaling through CD40, they exhibit the
       ability to induce T cell tolerance. The in vivo administration of
       anti-gp39 and allogeneic B cells diminished the ability of mice to mount
       an allogeneic response. Tolerance induction was specific for the
       haplotype expressed on the allogeneic B cells. Selective allospecific
       unresponsiveness was induced in the CD8 and CD4 compartments by the
       administration of anti-gp39 and class II-deficient B cells or class
       I-deficient B cells, respectively. As predicted by studies with
       anti-gp39 treatment, diminished allospecific responsiveness was induced
       by the administration of B cells to mice genetically deficient in gp39.
       Taken together, these data are consistent with the premise that
       deprivation of CD40 signaling engenders B cells with enhanced
       tolerogenicity. These studies provide insights into the tolerogenic
       capacity of resting B cells and outlines a practical approach to exploit
       this function.
 DE    Animal  Antibodies/PHARMACOLOGY  Antibodies, Monoclonal/IMMUNOLOGY
       Antigens, CD/*IMMUNOLOGY  Antigens, Differentiation,
       B-Lymphocyte/*IMMUNOLOGY  B-Lymphocytes/DRUG EFFECTS/*IMMUNOLOGY
       CD4-Positive T-Lymphocytes/IMMUNOLOGY  CD8-Positive
       T-Lymphocytes/IMMUNOLOGY  Female  Graft vs Host Reaction/IMMUNOLOGY
       Histocompatibility Antigens Class I/IMMUNOLOGY  Histocompatibility
       Antigens Class II/IMMUNOLOGY  Immune Tolerance/*IMMUNOLOGY
       Lipopolysaccharides/PHARMACOLOGY  Lymphocyte Culture Test, Mixed
       Membrane Glycoproteins/IMMUNOLOGY  Mice  Mice, Inbred Strains  Mice,
       Knockout  Signal Transduction/*IMMUNOLOGY  Support, Non-U.S. Gov't
       Support, U.S. Gov't, P.H.S.  T-Lymphocytes, Cytotoxic/IMMUNOLOGY
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).