Document 0170
 DOCN  M95A0170
 TI    Serodiagnosis of pericardial tuberculosis.
 DT    9510
 AU    Ng TT; Strang JI; Wilkins EG; Monsall Unit, North Manchester General
       Hospital, UK.
 SO    QJM. 1995 May;88(5):317-20. Unique Identifier : AIDSLINE MED/95316468
 AB    The AIDS epidemic has led to the resurgence of tuberculosis.
       Extrapulmonary manifestations may appear in over half of the patients
       who are dually infected. This has resulted in a rising incidence of
       tuberculous pericarditis in several parts of Africa such as Tanzania. We
       tested a solid-phase antibody competition sandwich ELISA (SACT-SE) as a
       potential means of diagnosing tuberculous pericarditis. Fifty-one
       African patients with clinically diagnosed tuberculous pericardial
       effusion (of whom 25 had confirmation by pericardial fluid culture) were
       tested using a monoclonal antibody (CDC/WHO ref. no. IT39) which was
       raised against a specific epitope on the Mycobacterium tuberculosis 30
       kDa antigen. All but one patient had negative sputum microscopy for
       acid-fast bacilli. A sensitivity of 61% (at 96% specificity) was
       achieved. Sera from 25 African patients with smear-positive tuberculosis
       were also examined; of which 20 tested positive (sensitivity 80%). This
       is the largest study to date on the potential application of serology in
       diagnosing pericardial tuberculosis.
 DE    Antibodies, Monoclonal/DIAGNOSTIC USE  Antigens, Bacterial/IMMUNOLOGY
       Enzyme-Linked Immunosorbent Assay  Evaluation Studies  Human
       Mycobacterium tuberculosis/IMMUNOLOGY  Pericarditis,
       Tuberculous/*DIAGNOSIS  Sensitivity and Specificity  Serodiagnosis
       Support, Non-U.S. Gov't  Tuberculosis, Pulmonary/DIAGNOSIS  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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