Document 0173
 DOCN  M95A0173
 TI    Synthesis and anti-HIV activity of new urea and nitrosourea derivatives
       of diamino acids.
 DT    9510
 AU    Dulude H; Salvador R; Gallant G; Medicinal Chemistry Laboratory, Faculty
       of Pharmacy, University; of Montreal, Quebec, Canada.
 SO    Bioorg Med Chem. 1995 Feb;3(2):151-60. Unique Identifier : AIDSLINE
       MED/95316428
 AB    A series of N1-methyl,N1-allyl,N1-(2-chloroethyl) and N1-propargyl urea
       and nitrosourea derivatives of diamino acids (L-ornithine and L-lysine)
       was synthesized and was shown to have weak activity in counteracting the
       cytopathic effects of the HIV-1 on a T4 lymphocyte cell line (CEM-IW).
       However, selected compounds may possess some immunomodulatory activity.
 DE    Amino Acids, Diamino/*CHEMICAL SYNTHESIS/PHARMACOLOGY  Antiviral
       Agents/*CHEMICAL SYNTHESIS/PHARMACOLOGY  Cell Line  Cell Survival/DRUG
       EFFECTS  Cytopathogenic Effect, Viral/DRUG EFFECTS  CD4-Positive
       T-Lymphocytes/DRUG EFFECTS/VIROLOGY  Human  HIV-1/*DRUG EFFECTS/GROWTH &
       DEVELOPMENT  Nitroso Compounds/*CHEMICAL SYNTHESIS/PHARMACOLOGY  Nuclear
       Magnetic Resonance  Support, Non-U.S. Gov't  Urea/*ANALOGS &
       DERIVATIVES/PHARMACOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).