Document 0197
 DOCN  M95A0197
 TI    [Oxidative stress and infectious pathology]
 DT    9510
 AU    Romero Alvira D; Guerrero Navarro L; Gotor Lazaro MA; Roche Collado E;
       Departement de Biochimie Clinique et de Diabetologie; Experimentale,
       CMU, Geneve, Switzerland.
 SO    An Med Interna. 1995 Mar;12(3):139-49. Unique Identifier : AIDSLINE
       MED/95315428
 AB    Pathogenic organism can be considered as pro-oxidant agents because they
       produce cell death and tissue damage. In addition organism can be
       eliminated by specific cell defense mechanism which utilize in part,
       reactive oxygen radicals formed by oxidative stress responses. The cause
       of the necessarily defense process results in cell damage thereby
       leading to development of inflammation, a characteristic oxidative
       stress situation. This fact shows the duality of oxidative stress in
       infections and inflammation: oxygen free radicals protect against
       microorganism attack and can produce tissue damage during this
       protection to trigger inflammation. Iron, a transition metal which
       participates generating oxygen free radicals, displays also this duality
       in infection. We suggest also that different infectious pathologies,
       such as sickle cell anemia/malaria and AIDS, may display in part this
       duality. In addition, it should be noted that oxidative damage observed
       in infectious diseases is mostly due the inflammatory response than to
       the oxidative potential of the pathogenic agent, this last point is
       exemplified in cases of respiratory distress and in glomerulonephritis.
       This review analyzes these controversial facts of infectious pathology
       in relation with oxidative stress.
 DE    Acquired Immunodeficiency Syndrome/METABOLISM  Adult  Anemia, Sickle
       Cell/METABOLISM  Animal  Antioxidants/METABOLISM  Arachidonic
       Acid/METABOLISM  Ascorbic Acid/METABOLISM  Cells, Cultured  Child
       Comparative Study  Endotoxins/METABOLISM  English Abstract
       Fetus/METABOLISM  Free Radicals  Glomerulonephritis/METABOLISM  Human
       Infection/*METABOLISM  Inflammation/METABOLISM  Iron/METABOLISM
       Malaria/METABOLISM  Mice  *Oxidative Stress  Phagocytosis  Rabbits
       Respiratory Distress Syndrome, Adult/METABOLISM  Sheep  JOURNAL ARTICLE
       REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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