Document 0200
 DOCN  M95A0200
 TI    Recommendations for treatment of chancroid, 1993.
 DT    9510
 AU    Schulte JM; Schmid GP; Epidemiology Research Branch, Centers for Disease
       Control and; Prevention, Atlanta, Georgia 30333, USA.
 SO    Clin Infect Dis. 1995 Apr;20 Suppl 1:S39-46. Unique Identifier :
       AIDSLINE MED/95315412
 AB    Since the 1989 Sexually Transmitted Diseases Treatment Guidelines were
       published by the Centers for Disease Control and Prevention, changes in
       the efficacy of the recommended and alternative regimens for the
       treatment of Haemophilus ducreyi infections have been described. Among
       recommended agents, erythromycin remains effective, and although a
       single dose of ceftriaxone appears to remain effective in the United
       States, limited data from Kenya have shown that this regimen has been
       associated with treatment failures. Of alternative treatment regimens,
       trimethoprim-sulfamethoxazole has been associated with widespread
       failure, but little work has been done to further evaluate the efficacy
       of the amoxicillin/clavulanic acid and ciprofloxacin regimens. Of the
       new antimicrobials, azithromycin has been very effective in the United
       States, but the efficacy of this drug elsewhere has not been thoroughly
       evaluated. Fleroxacin has been very effective in Kenya. Data from Africa
       indicate that patients who are infected with the human immunodeficiency
       virus do not respond to therapy as well as patients who are not, and
       patients who are uncircumcised may not respond as well to therapy as do
       patients who are circumcised.
 DE    Antibiotics/THERAPEUTIC USE  Chancroid/*DRUG THERAPY  Human  JOURNAL
       ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).