Document 0212
 DOCN  M95A0212
 TI    Effect of splenectomy on T lymphocyte subsets in patients infected with
       the human immunodeficiency virus.
 DT    9510
 AU    Zurlo JJ; Wood L; Gaglione MM; Polis MA; Division of Infectious
       Diseases, Milton S. Hershey Medical; Center, Hershey, Pennsylvania
       17033, USA.
 SO    Clin Infect Dis. 1995 Apr;20(4):768-71. Unique Identifier : AIDSLINE
       MED/95315373
 AB    A case-control study was conducted at two institutions to determine
       whether the absolute CD4 lymphocyte count or the percentage of
       lymphocytes bearing the CD4 marker (i.e., the CD4 percentage) is a more
       accurate indicator of underlying immune status in splenectomized
       patients infected with human immunodeficiency virus (HIV). Each of nine
       splenectomized HIV-infected cases was matched with six nonsplenectomized
       HIV-infected controls--three matched for CD4 lymphocyte count and three
       for CD4 percentage. In analyses including the eight cases with an
       initial CD4 lymphocyte count of > 200/mm3, controlling for the CD4 count
       revealed differences between cases and controls in terms of CD4
       percentage (range, 10%-41% and 17%-54%, respectively; P < .01) and
       Centers for Disease Control and Prevention (CDC) clinical stage (P =
       .06). Controlling for the CD4 percentage revealed a significant
       difference between cases and controls in terms of CD4 count (range,
       396-1,040 and 55-784 cells/mm3, respectively; P < .01) but not CDC
       clinical stage (P > .7). These data suggest that the numerical
       relationship between the CD4 lymphocyte count and the CD4 percentage
       among splenectomized HIV-infected patients with more than 200 CD4
       cells/mm3 differs from that among nonsplenectomized patients. The CD4
       percentage appears to be a more accurate indicator of the underlying
       level of immune function in the former group of patients.
 DE    Adolescence  Adult  Case-Control Studies  CD4 Lymphocyte Count
       *CD4-Positive T-Lymphocytes  Human  HIV Infections/*IMMUNOLOGY  Male
       *Splenectomy  *T-Lymphocyte Subsets  JOURNAL ARTICLE

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