Document 0225
 DOCN  M95A0225
 TI    CD4+ but not CD8+ T cells are required for the induction of oral
       tolerance.
 DT    9510
 AU    Garside P; Steel M; Liew FY; Mowat AM; Department of Immunology, Western
       Infirmary, University of; Glasgow, UK.
 SO    Int Immunol. 1995 Mar;7(3):501-4. Unique Identifier : AIDSLINE
       MED/95315099
 AB    It has been suggested that oral tolerance is mediated by CD8+ T
       lymphocytes, but the functional properties of these cells are unclear.
       Here we show that the induction of tolerance by feeding mice ovalbumin
       (OVA) does not prime antigen-specific class I MHC-restricted cytotoxic T
       cells in vivo. Indeed, such responses are markedly suppressed in mice
       fed OVA, and the induction of oral tolerance is abolished by depletion
       in vivo of CD4+ but not CD8+ T cells. These results indicate that CD8+
       lymphocytes are unlikely to play a major role in the induction of oral
       tolerance and are the first demonstration that specific cytotoxic
       responses to an exogenous antigen can be suppressed by feeding antigen.
 DE    Administration, Oral  Animal  Antigen Presentation
       Antigens/*ADMINISTRATION & DOSAGE/IMMUNOLOGY  CD4-Positive
       T-Lymphocytes/*IMMUNOLOGY  CD8-Positive T-Lymphocytes/*IMMUNOLOGY
       Desensitization, Immunologic  Female  H-2 Antigens/IMMUNOLOGY
       Hypersensitivity, Delayed/IMMUNOLOGY/PREVENTION & CONTROL  Immune
       Tolerance/*IMMUNOLOGY  Mice  Mice, Inbred C57BL
       Ovalbumin/ADMINISTRATION & DOSAGE/IMMUNOLOGY  Support, Non-U.S. Gov't
       T-Lymphocytes, Cytotoxic/IMMUNOLOGY  JOURNAL ARTICLE

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