Document 0226
 DOCN  M95A0226
 TI    Expansion of CD8+CD57+ T cells after allogeneic BMT is related with a
       low incidence of relapse and with cytomegalovirus infection.
 DT    9510
 AU    Dolstra H; Preijers F; Van de Wiel-van Kemenade E; Schattenberg A;
       Galama J; de Witte T; Department of Internal Medicine, University
       Hospital Nijmegen,; The Netherlands.
 SO    Br J Haematol. 1995 Jun;90(2):300-7. Unique Identifier : AIDSLINE
       MED/95315012
 AB    Peripheral blood lymphocytes of 46 recipients of lymphocyte-depleted
       bone marrow allografts were phenotypically analysed over a period of 1
       year. We investigated the repopulation of lymphocyte subpopulations and
       their relation with clinical parameters such as graft-versus-host
       disease (GVHD), graft-versus-leukaemia and cytomegalovirus (CMV)
       infection. The number of repopulated T cells varied strongly between the
       blood samples of the recipients. In 45% of the recipients the number of
       T cells recovered to or above normal levels within 3 months after bone
       marrow transplantation (BMT), whereas the other recipients remained
       below normal up to 1 year after BMT. In recipients with a high
       repopulation, the CD8+ T-cell subset contributed more to this high
       repopulation than the CD4+ T-cell subset. We showed that the majority of
       T cells of these recipients expressed the alpha beta T-cell receptor,
       CD8, CD57 and CD11b. HLA-DR was also highly expressed reflecting the
       activation stage of T cells in these recipients. BMT recipients with a
       high repopulation of CD8+ T cells showed a lower incidence of leukaemic
       relapse than recipients with a low repopulation. The 3-year probability
       of relapse was 19% versus 64% (P = 0.03), respectively. The relative
       high number of CD8+ T cells at 3 months after BMT was not associated
       with the incidence of GVHD. In contrast, occurrence of CMV infection
       after BMT was significantly higher in these recipients. Our results
       indicate that CD8+ T cells, predominantly CD57+, of BMT recipients with
       an expansion of these cells represent an in vivo activated cell
       population. This CD8+ T-cell population may consist partially of
       cytotoxic cells with anti-leukaemic activity as suggested by a low
       relapse rate. The signal for the strong expansion of these CD8+CD57+ T
       cells after BMT is still unclear, but association with CMV infection
       suggests that viral antigens are involved.
 DE    Adolescence  Adult  Anemia/IMMUNOLOGY  Antigens, CD/*IMMUNOLOGY
       Antigens, Differentiation, T-Lymphocyte/*IMMUNOLOGY  *Bone Marrow
       Transplantation  Cytomegalovirus Infections/IMMUNOLOGY  CD8-Positive
       T-Lymphocytes/*IMMUNOLOGY  Female  Graft vs Host Disease/IMMUNOLOGY
       Human  Leukemia/IMMUNOLOGY/*THERAPY  Lymphoma/IMMUNOLOGY  Male  Middle
       Age  Recurrence  Support, Non-U.S. Gov't  T-Lymphocyte
       Subsets/*IMMUNOLOGY  JOURNAL ARTICLE

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