Document 0249
 DOCN  M95A0249
 TI    Rates of p24 antigenemia and viral isolation in comparable white and
       black HIV-infected subjects. Military Medical Consortium for Applied
       Retroviral Research.
 DT    9510
 AU    Brown AE; Lane JR; Wagner KF; Zhou S; Chung R; Ray KL; Blatt SP; Burke
       DS; Division of Retrovirology, Walter Reed Army Institute of; Research,
       Washington, DC, USA.
 SO    AIDS. 1995 Apr;9(4):325-8. Unique Identifier : AIDSLINE MED/95314786
 AB    OBJECTIVE: To determine the relative frequencies of HIV-1 p24 antigen
       and culture positivity in white and black patients. DESIGN: Volunteers
       in the US military's HIV natural history study were 46% white, 44%
       black, 7% Hispanic and 3% other. Focusing on the comparable groups of
       whites and blacks, a retrospective analysis was performed of the results
       of virologic assays collected over a 2-year period. METHODS: p24 antigen
       was quantitated in sera with and without immune complex dissociation
       (ICD); viral isolation was performed by coculture of peripheral blood
       mononuclear cells. RESULTS: Results of the two virologic assays were
       very similar in the two racial groups, both overall and after
       stratification by CD4 cell count. As reported previously, the
       concentration of serum immunoglobulin G was found to be greater in black
       than white subjects. In contrast to results with ICD, sera tested
       without ICD resulted in differing (higher) rates of antigenemia in
       whites than blacks (P = 0.002). CONCLUSIONS: The frequencies of p24
       antigen and culture positivity were found to be independent of race.
       Previously observed racial differences in antigen positivity were likely
       to be due to more extensive antibody binding in blacks than in whites.
 DE    Adult  *Caucasoid Race  Comparative Study  CD4-Positive T-Lymphocytes
       Female  Human  HIV Core Protein p24/*BLOOD  HIV
       Infections/BLOOD/EPIDEMIOLOGY/*VIROLOGY  HIV-1/IMMUNOLOGY/*ISOLATION &
       PURIF  Leukocyte Count  Leukocytes, Mononuclear/VIROLOGY  Male  Military
       Personnel  *Negroid Race  Retrospective Studies  Support, U.S. Gov't,
       Non-P.H.S.  United States/EPIDEMIOLOGY  Viremia/EPIDEMIOLOGY  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).