Document 0264
 DOCN  M95A0264
 TI    Immunoglobulin E levels in relationship to HIV-1 disease, route of
       infection, and vitamin E status.
 DT    9510
 AU    Miguez-Burbano MJ; Shor-Posner G; Fletcher MA; Lu Y; Moreno JN; Carcamo
       C; Page B; Quesada J; Sauberlich H; Baum MK; Department of Epidemiology
       and Public Health, University of Miami; School of Medicine, FL 33101,
       USA.
 SO    Allergy. 1995 Feb;50(2):157-61. Unique Identifier : AIDSLINE
       MED/95328678
 AB    Our recent studies have demonstrated that in early HIV-1 infection,
       elevation of plasma immunoglobulin E (IgE) levels precedes the decline
       of CD4 cell count and is influenced by vitamin E status. In order to
       further investigate the role of IgE elevation in HIV-1 infection, we
       determined IgE levels in HIV-1-seropositive and -seronegative
       intravenous drug users (IDUs) (n = 38), in relationship to cellular and
       humoral immune function, liver enzymes, and vitamin E status. To examine
       the possible impact of the route of HIV-1 infection on IgE levels,
       comparisons between the cohorts of the HIV-1-seropositive and
       seronegative IDUs and homosexual men (n = 45) were also conducted. All
       HIV-1-seropositive participants had significantly higher (P = 0.003) IgE
       levels than the HIV-1-seronegative subjects. The HIV-1-seropositive
       IDUs, moreover, demonstrated significantly higher (P = 0.01) IgE levels
       than HIV-1-seropositive homosexual men, despite similar CD4 cell counts.
       Stepwise regression analysis was used to evaluate the possible variables
       contributing to the IgE variation. HIV-1 status (P = 0.0009),
       intravenous drug use (P = 0.014), CD8 cell counts (P = 0.0001), plasma
       level of vitamin E (P = 0.006), and alcohol intake (P = 0.047) were
       significant, accounting for 71% of the IgE elevation. These findings
       suggest that IgE may serve as a sensitive marker to reflect the
       evolution of HIV-1 disease in individuals from different risk groups.
 DE    Acquired Immunodeficiency Syndrome/BLOOD/*IMMUNOLOGY/TRANSMISSION  CD4
       Lymphocyte Count  Female  Homosexuality, Male  Human  HIV
       Seronegativity/IMMUNOLOGY  HIV Seropositivity/IMMUNOLOGY  *HIV-1
       IgE/*ANALYSIS  Male  Nutritional Status  Serum Albumin/ANALYSIS
       Substance Abuse, Intravenous/COMPLICATIONS/IMMUNOLOGY  Support, U.S.
       Gov't, P.H.S.  Vitamin E/*BLOOD  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).