Document 0265
 DOCN  M95A0265
 TI    Peripheral blood T lymphocytes in seasonal bronchial asthma.
 DT    9510
 AU    Monteseirin J; Guardia P; Delgado J; Llamas E; Palma J; Conde A; Conde
       J; Servicio de Inmunologia y Alergia, Hospital Universitario Virgen;
       Macarena, Seville, Spain.
 SO    Allergy. 1995 Feb;50(2):152-6. Unique Identifier : AIDSLINE MED/95328677
 AB    Variations in T lymphocytes in asthmatic patients are related to disease
       severity. However, the effects of natural exposure to pollens on
       peripheral blood T lymphocytes have not been clarified. In this paper,
       the effects on peripheral blood CD4 and CD8 lymphocytes from
       pollen-sensitive subjects and from nonatopic donors were studied during
       and outside the pollen season. In patients who suffer from seasonal
       asthma, we found an increase in the CD4/CD8 bright ratio and a decrease
       in the mean number of CD4 receptors per cell during the pollen season.
       No variation was observed in healthy subjects. These results suggest
       that CD4 lymphocytes may be causally linked to the pathogenesis of
       seasonal bronchial asthma.
 DE    Adolescence  Adult  *Allergens  Antigens, CD4/ANALYSIS
       Asthma/ETIOLOGY/*IMMUNOLOGY  *CD4-CD8 Ratio  Female  Flow Cytometry
       Human  Male  *Pollen  *Seasons  JOURNAL ARTICLE

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