Document 0271
 DOCN  M95A0271
 TI    Hyperferritinemia in reactive hemophagocytic syndrome report of four
       adult cases.
 DT    9510
 AU    Koduri PR; Carandang G; DeMarais P; Patel AR; Department of Medicine,
       Cook County Hospital, Chicago, Illinois,; USA.
 SO    Am J Hematol. 1995 Jul;49(3):247-9. Unique Identifier : AIDSLINE
       MED/95328548
 AB    Four patients were diagnosed with reactive hemophagocytic syndrome
       (RHPS) during a 7 month period. Of these, three patients were diagnosed
       with acquired immunodeficiency syndrome complicated by disseminated
       Mycobacterium tuberculosis infection, incompletely treated Pneumocystis
       carinii pneumonia and disseminated histoplasmosis respectively. The
       fourth patient had non-Hodgkin's lymphoma of the mature T-cell
       phenotype. Fever, bicytopenia, or pancytopenia, elevated serum lactate
       dehydrogenase (LDH) level (> 1,000 IU/L), and hemophagocytic
       histiocytosis in smears of bone marrow aspirate were present in all
       patients. Hyperferritinemia (> 10,000 ng/ml) was present in all (range
       34,976 to 425,984 ng/mL) and showed a decrease in the two patients who
       responded to therapy. Hyperferritinemia (> 10,000 ng/ml) and elevated
       serum LDH (> 1,000 IU/L) are important clues to the diagnosis of RHPS in
       the febrile cytopenic patient with immunodeficiency.
 DE    Acquired Immunodeficiency Syndrome/COMPLICATIONS  Adult  Bone
       Marrow/PATHOLOGY  Case Report  Ferritin/*BLOOD  Histiocytosis,
       Non-Langerhans-Cell/COMPLICATIONS/*DIAGNOSIS/  PATHOLOGY
       Histoplasmosis/COMPLICATIONS/DRUG THERAPY  Human  Lactate
       Dehydrogenase/BLOOD  Lymphoma, Non-Hodgkin's/COMPLICATIONS/DRUG THERAPY
       Male  Middle Age  Pneumonia, Pneumocystis carinii/COMPLICATIONS/DRUG
       THERAPY  Tuberculosis/COMPLICATIONS/DRUG THERAPY  JOURNAL ARTICLE

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