Document 0272
 DOCN  M95A0272
 TI    Higher cytotoxic activity and increased levels of IL-1 beta, IL-6, and
       TNF-alpha in patients undergoing cardiopulmonary bypass.
 DT    9510
 AU    Marti F; Munoz J; Peiro M; Bertran E; Ferran C; Octavio C; Garcia J;
       Rueda F; Department of Cryobiology and Cell Therapy, Ciutat Sanitaria i;
       Universitaria de Bellvitge, L'Hospitalet de Llobregat,; Barcelona,
       Spain.
 SO    Am J Hematol. 1995 Jul;49(3):237-9. Unique Identifier : AIDSLINE
       MED/95328544
 AB    Extracorporeal circulation (EC) by surgical bypass is often associated
       with a systemic inflammatory response. The purpose of this study was to
       assess the effect of EC on the serum levels of pro-inflammatory
       mediators Interleukin (IL)-1 beta, IL-6, tumor necrosis factor
       (TNF)-alpha, and soluble CD-23. Peripheral blood lymphocyte subsets and
       natural killer cell (NK) cytotoxic activity were also analyzed before
       and after the bypass process. The results from eight patients who
       underwent cardiac surgery showed a significant increase in the levels of
       IL-1 beta, IL-6, and TNF-alpha, a decrease in CD4+/CD8+ lymphocyte
       ratio, and an overstimulated NK cytotoxic activity. These changes on
       serum cytokine levels and cellular immunology parameters could play an
       important role in the development of adverse effects associated with EC.
 DE    Aged  *Cardiopulmonary Bypass/ADVERSE EFFECTS  *Cytotoxicity,
       Immunologic  CD4-CD8 Ratio  Female  Human  Interleukin-1/*METABOLISM
       Interleukin-6/*METABOLISM  Killer Cells, Natural/IMMUNOLOGY  Male
       Middle Age  Support, Non-U.S. Gov't  Tumor Necrosis Factor/*METABOLISM
       JOURNAL ARTICLE

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