Document 0273
 DOCN  M95A0273
 TI    Idiopathic CD4+ T-lymphocytopenia in HIV seronegative men with
       hemophilia and sex partners of HIV seropositive men. Multicenter
       Hemophilia Cohort Study.
 DT    9510
 AU    O'Brien TR; Diamondstone L; Fried MW; Aledort LM; Eichinger S; Eyster
       ME; Hilgartner MW; White G; Di Bisceglie AM; Goedert JJ; Viral
       Epidemiology Branch, National Cancer Institute, Rockville,; MD 20852,
       USA.
 SO    Am J Hematol. 1995 Jul;49(3):201-6. Unique Identifier : AIDSLINE
       MED/95328539
 AB    Persons with hemophilia or other HIV-1 risk factors may be more likely
       to have idiopathic CD4+ T-lymphocytopenia (ICL). We determined the
       frequency of ICL in prospectively followed cohorts of HIV-1 seronegative
       hemophilic men and seronegative female sex partners of HIV-1 infected
       hemophilic men, and examined factors potentially associated with ICL.
       Seven of 304 (2.3%) seronegative hemophilic men and one of 160 (0.6%)
       female partners met the ICL definition, but the condition resolved for
       two of the men and for the sole female partner. All five men with
       persistent ICL had lymphocytopenia (< 1,200 total
       lymphocytes/microliters) and < 300 total CD4+ lymphocytes/microliters;
       only one had a low CD4+ percentage. On the most recent measurement,
       14.5% of the 304 seronegative hemophilic men had lymphocytopenia.
       Compared with matched hemophilic controls, men with persistent ICL more
       often had a history of liver disease (3/5 cases, 0/21 controls, P =
       0.007) or splenomegaly (3/5 cases, 4/21 controls; P = 0.04), but not
       severe hemophilia, greater clotting factor concentrate exposure, high
       alanine aminotransferase levels, hepatitis B virus antigenemia, or
       detectable hepatitis C virus RNA in plasma. All five cases and 20/21
       controls had antibodies to hepatitis C virus present in their serum. In
       this cohort of hemophilic men, ICL was related to lymphocytopenia
       associated with liver disease rather than selective loss of CD4+
       lymphocytes.
 DE    Acquired Immunodeficiency Syndrome/COMPLICATIONS  Adult  Case-Control
       Studies  *CD4-Positive T-Lymphocytes  Female  Hemophilia/*COMPLICATIONS
       Hepatitis Antibodies/BLOOD  Hepatitis C Viruses/IMMUNOLOGY  Human  HIV
       Seronegativity  *HIV Seropositivity  Liver Diseases/COMPLICATIONS
       Lymphopenia/*COMPLICATIONS  Male  Middle Age  Prospective Studies
       *Sexual Partners  Splenomegaly  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).