Document 0282
 DOCN  M95A0282
 TI    Constitutively activated Jak-STAT pathway in T cells transformed with
       HTLV-I.
 DT    9510
 AU    Migone TS; Lin JX; Cereseto A; Mulloy JC; O'Shea JJ; Franchini G;
       Leonard WJ; Laboratory of Molecular Immunology, National Heart, Lung,
       and; Blood Institute, National Institutes of Health, Bethesda, MD;
       20892, USA.
 SO    Science. 1995 Jul 7;269(5220):79-81. Unique Identifier : AIDSLINE
       MED/95327953
 AB    Human T cell lymphotropic virus I (HTLV-I) is the etiological agent for
       adult T cell leukemia and tropical spastic paraparesis (also termed
       HTLV-I-associated myelopathy). HTLV-I-infected peripheral blood T cells
       exhibit an initial phase of interleukin-2 (IL-2)-dependent growth; over
       time, by an unknown mechanism, the cells become IL-2-independent.
       Whereas the Jak kinases Jak1 and Jak3 and the signal transducer and
       activator of transcription proteins Stat3 and Stat5 are activated in
       normal T cells in response to IL-2, this signaling pathway was
       constitutively activated in HTLV-I-transformed cells. In HTLV-I-infected
       cord blood lymphocytes, the transition from IL-2-dependent to
       IL-2-independent growth correlated with the acquisition of a
       constitutively activated Jak-STAT pathway, which suggests that this
       pathway participates in HTLV-I-mediated T cell transformation.
 DE    Base Sequence  Cell Line, Transformed  *Cell Transformation, Viral
       Cells, Cultured  DNA-Binding Proteins/*METABOLISM  Enzyme Activation
       Fetal Blood/CYTOLOGY  Human  HTLV-I/*PHYSIOLOGY
       Interleukin-2/PHARMACOLOGY  Molecular Sequence Data  Phosphorylation
       Protein-Tyrosine Kinase/*METABOLISM  Receptors, Interleukin-2/METABOLISM
       Signal Transduction  Support, Non-U.S. Gov't
       T-Lymphocytes/METABOLISM/*VIROLOGY  Trans-Activators/*METABOLISM
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).