Document 0292
 DOCN  M95A0292
 TI    Synergy between T-cell immunity and inhibition of paracrine stimulation
       causes tumor rejection.
 DT    9510
 AU    Seung LP; Rowley DA; Dubey P; Schreiber H; Department of Pathology,
       University of Chicago, IL 60637, USA.
 SO    Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6254-8. Unique Identifier :
       AIDSLINE MED/95327625
 AB    During tumor progression, variants may arise that grow more vigorously.
       The fate of such variants depends upon the balance between
       aggressiveness of the variant and the strength of the host immunity.
       Although enhancing host immunity to cancer is a logical objective,
       eliminating host factors necessary for aggressive growth of the variant
       should also be considered. The present study illustrates this concept in
       the model of a spontaneously occurring, progressively growing variant of
       an ultraviolet light-induced tumor. The variant produces chemotactic
       factors that attract host leukocytes and is stimulated in vitro by
       defined growth factors that can be produced or induced by leukocytes.
       This study also shows that CD8+ T-cell immunity reduces the rate of
       tumor growth; however, the variant continues to grow and kills the host.
       Treatment with a monoclonal anti-granulocyte antibody that counteracts
       the infiltration of the tumor cell inoculum by non-T-cell leukocytes did
       not interfere with the CD8+ T-cell-mediated immune response but resulted
       in rejection of the tumor challenge, indicating a synergy between CD8+
       T-cell-mediated immunity and the inhibition of paracrine stimulation.
 DE    Animal  Ascitic Fluid/IMMUNOLOGY  Bone Marrow/IMMUNOLOGY/PATHOLOGY
       Cytotoxicity, Immunologic  CD8-Positive T-Lymphocytes/IMMUNOLOGY  Growth
       Substances/BIOSYNTHESIS/PHYSIOLOGY  Immunity, Cellular
       Leukocytes/IMMUNOLOGY  Lymphocytes,
       Tumor-Infiltrating/IMMUNOLOGY/PATHOLOGY  Mice  Mice, Inbred BALB C
       Mice, Inbred C3H  Mice, Nude  Neoplasms,
       Radiation-Induced/*IMMUNOLOGY/PATHOLOGY  Support, U.S. Gov't, P.H.S.
       T-Lymphocytes/*IMMUNOLOGY  T-Lymphocytes, Cytotoxic/*IMMUNOLOGY  Time
       Factors  Tumor Cells, Cultured  Ultraviolet Rays  Variation (Genetics)
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).