Document 0298
 DOCN  M95A0298
 TI    Invasive group B streptococcal disease in children beyond early infancy.
 DT    9510
 AU    Hussain SM; Luedtke GS; Baker CJ; Schlievert PM; Leggiadro RJ;
       Department of Pediatrics, University of Tennessee, Memphis, USA.
 SO    Pediatr Infect Dis J. 1995 Apr;14(4):278-81. Unique Identifier :
       AIDSLINE MED/95327443
 AB    There is little information available on invasive group B Streptococcus
       (GBS) infection in pediatric patients older than 3 months of age. Review
       of infection control records at LeBonheur Children's Medical Center from
       January 1, 1986, to June 30, 1993, identified 143 patients with a
       positive GBS culture from normally sterile body fluid. Medical records
       of 18 (13%) patients > 3 months old with their first GBS infection were
       reviewed. Age range was 15 weeks to 18 years (median age, 13 months).
       Ten were black and 11 were girls. Five infants had a history of
       premature birth and 2 infants were infected with human immunodeficiency
       virus. The serotype distribution of 12 available GBS isolates was 4 type
       III, 2 each type V and Ia and 1 each type Ia/c, Ib/c, II and II/c.
       Bacteremia without a focus (9 patients) was the most common clinical
       manifestation. All 4 type III isolates were associated with bacteremia.
       One infant with human immunodeficiency virus infection had sepsis and
       bullous desquamation; a toxin-producing type V strain was isolated from
       her blood. Two adolescents with ventriculoperitoneal shunts had
       meningitis, including one whose cerebrospinal fluid also grew a type V
       strain. Other clinical manifestations were septic arthritis,
       endocarditis (Ia, II/c), central venous catheter (Ia/c) and
       ventriculostomy infections.
 DE    Adolescence  Age of Onset  Age Distribution  Antibiotics/THERAPEUTIC USE
       Bacteremia/DRUG THERAPY/*EPIDEMIOLOGY/PHYSIOPATHOLOGY  Child  Child,
       Preschool  Female  Human  Incidence  Infant  Male  Retrospective Studies
       Streptococcal Infections/DRUG THERAPY/*EPIDEMIOLOGY/  PHYSIOPATHOLOGY
       Streptococcus agalactiae/*ISOLATION & PURIF  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).